RGS6

This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known. [provided by RefSeq, Mar 2011]

Description

Regulator of G protein signaling 6

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Nucleoli, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (71932429 - 72566530)

Ensembl ID

ENSG00000182732  (ver. 103.38)

Orthologs

Mouse Rgs6: ENSMUSG00000021219

UniProt

P49758

neXtProt

NX_P49758

Human splice variants
Mouse splice variants

Protein structure