NISCH

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]

Description

Nischarin

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Microtubules, Cytokinetic bridge, Cytosol

Predicted location

Intracellular

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (52455118 - 52493068)

Ensembl ID

ENSG00000010322  (ver. 103.38)

Orthologs

Mouse Nisch: ENSMUSG00000021910

UniProt

Q9Y2I1

neXtProt

NX_Q9Y2I1

Human splice variants
Mouse splice variants

Protein structure