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- Antigen structure
- References [5]
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- Western blot [1]
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- Product number
- 14662-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14662-1-AP, RRID:AB_2242609
- Product name
- AFF4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AFF4 antibody (Cat. #14662-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression.
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription.
Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy.
A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.
Zheng B, Aoi Y, Shah AP, Iwanaszko M, Das S, Rendleman EJ, Zha D, Khan N, Smith ER, Shilatifard A
Genes & development 2021 Feb 1;35(3-4):273-285
Genes & development 2021 Feb 1;35(3-4):273-285
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription.
Tang D, Chen C, Liao G, Liu J, Liao B, Huang Q, Chen Q, Zhao J, Jiang H, Duan J, Huang J, Wang K, Wang J, Zhou C, Chu W, Li W, Sun B, Li Z, Dai L, Fu X, Cheng W, Xue Y, Qi S
Cell discovery 2020;6:7
Cell discovery 2020;6:7
Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy.
Liang K, Smith ER, Aoi Y, Stoltz KL, Katagi H, Woodfin AR, Rendleman EJ, Marshall SA, Murray DC, Wang L, Ozark PA, Mishra RK, Hashizume R, Schiltz GE, Shilatifard A
Cell 2018 Oct 18;175(3):766-779.e17
Cell 2018 Oct 18;175(3):766-779.e17
A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.
Wu J, Ao MT, Shao R, Wang HR, Yu D, Fang MJ, Gao X, Wu Z, Zhou Q, Xue YH
Scientific reports 2017 Sep 6;7(1):10657
Scientific reports 2017 Sep 6;7(1):10657
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II.
Lu X, Zhu X, Li Y, Liu M, Yu B, Wang Y, Rao M, Yang H, Zhou K, Wang Y, Chen Y, Chen M, Zhuang S, Chen LF, Liu R, Chen R
Nucleic acids research 2016 Aug 19;44(14):6853-67
Nucleic acids research 2016 Aug 19;44(14):6853-67
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AFF4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AFF4. This antibody recognizes human, mouse, rat antigen. The AFF4 antibody has been validated for the following applications: ELISA, WB analysis.
