Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS60989 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SNCA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human SNCA.
- Description
- The synuclein family members, including Ï«-synuclein (also designated NACP for non--ÉÇ-Amyloid component) and ÉÇ-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. Ï«-synuclein is localized to neuronal cell bodies and synapses. Ï«-synuclein was first identified as a component of Alzheimer£ªs disease amyloid plaques. Abnormal platelet function in Alzheimer£ªs disease has been demonstrated. During megakaryocytic differentiation Ï«-synuclein has been found to be upregulated, while ÉÇ-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of Ï«-synuclein has been found in patients with early onset Parkinson£ªs disease.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of SNCA pAb at 1:500 dilution Lane1:HEK293T whole cell lysateLane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate