R-060-100

antibody from Biosensis Pty Ltd

Targeting: SNCA NACP, PARK1, PARK4, PD1

Western blot (Recommended by provider)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

R-060-100

Provider

Biosensis Pty Ltd

Proper citation

Biosensis Cat#R-060-100, RRID:AB_2492699

Product name

Rabbit antibody to pan synuclein: whole serum

Antibody type

Polyclonal

Antigen

Synthetic peptide

Description

A synthetic peptide (AKEGVVAAAEKTKQGV) as a consensus part of human alpha-, beta-, and gamma synuclein proteins conjugated to diphteria toxoid has been used as the immunogen.

Reactivity

Human, Rat

Host

Rabbit

Antigen sequence

AKEGVVAAAEKTKQGV


Vial size

100 µl

Storage

Lyophilised. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Handling

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

References

Submitted references

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties.

Näsström T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergström J
Free radical biology & medicine 2011 Feb 1;50(3):428-37

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Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.

Ulusoy A, Febbraro F, Jensen PH, Kirik D, Romero-Ramos M
The European journal of neuroscience 2010 Aug;32(3):409-22

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Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.

Mukaetova-Ladinska EB, Milne J, Andras A, Abdel-All Z, Cerejeira J, Greally E, Robson J, Jaros E, Perry R, McKeith IG, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I
Dementia and geriatric cognitive disorders 2008;26(1):32-42

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Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D
Brain : a journal of neurology 2007 Mar;130(Pt 3):799-815