Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [3]
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Validation data
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- Product number
- NBP1-04321 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-04321, RRID:AB_1522485
- Product name
- Mouse Monoclonal alpha-Synuclein Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson's disease and multiple system atrophy.
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.
Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).
De Luca CMG, Elia AE, Portaleone SM, Cazzaniga FA, Rossi M, Bistaffa E, De Cecco E, Narkiewicz J, Salzano G, Carletta O, Romito L, Devigili G, Soliveri P, Tiraboschi P, Legname G, Tagliavini F, Eleopra R, Giaccone G, Moda F
Translational neurodegeneration 2019;8:24
Translational neurodegeneration 2019;8:24
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.
Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR
Neuron 2018 Jan 3;97(1):92-107.e10
Neuron 2018 Jan 3;97(1):92-107.e10
Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA).
Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG
The Journal of biological chemistry 2014 Apr 25;289(17):11897-905
The Journal of biological chemistry 2014 Apr 25;289(17):11897-905
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: alpha-Synuclein Antibody (5C2) [NBP1-04321] - The recombinant human synuclein family (alpha-, beta- and gamma-) and alpha-synuclein domains (1-60, 1-95, 61-140 and 96-140) proteins were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-alpha-Synuclein (61-95 aa) antibody (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: alpha-Synuclein Antibody (5C2) [NBP1-04321] - The recombinant human synuclein family proteins were resolved by SDS-PAGE, transferred to PVDF membrane and probed with human anti-alpha-Synuclein antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant human alpha-synuclein Lane 2.: Recombinant human beta-synuclein Lane 3.: Recombinant human gamma-synuclein
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: alpha-Synuclein Antibody (5C2) [NBP1-04321] - The recombinant human alpha-synuclein domains were resolved by SDS-PAGE, transferred to PVDF membrane and probed with human anti-alpha-Synuclein(61-95aa) antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant human alpha-synuclein(1-60aa) Lane 2.: Recombinant human alpha-synuclein(1-95aa) Lane 3.: Recombinant human alpha-synuclein(61-140aa) Lane 4.: Recombinant human alpha-synuclein(96-140aa)