Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 12108-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12108-1-AP, RRID:AB_2209469
- Product name
- TRIM21 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM21 antibody (Cat. #12108-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro.
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Yao L, Xu L, Zhou L, Wu S, Zou W, Chen M, Chen J, Peng H
Frontiers in cell and developmental biology 2021;9:685913
Frontiers in cell and developmental biology 2021;9:685913
The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway.
Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Cellular and molecular gastroenterology and hepatology 2021;11(5):1369-1385
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA(A) R-Dependent TRIM21 Modulation of Src Expression.
Liu Q, Sheng Z, Cheng C, Zheng H, Lanuti M, Liu R, Wang P, Shen Y, Xie Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Sep;8(18):e2102079
Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma.
Gao L, Xia L, Ji W, Zhang Y, Xia W, Lu S
Translational oncology 2021 Sep;14(9):101148
Translational oncology 2021 Sep;14(9):101148
WIPI-1 inhibits metastasis and tumour growth via the WIPI-1-TRIM21 axis and MYC regulation in nasopharyngeal carcinoma.
Zhao Y, Li WF, Li QJ, He SW, He QM, Long LF, Liu N, Ma J
Oral oncology 2021 Nov;122:105576
Oral oncology 2021 Nov;122:105576
Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells.
Qi H, Wang L, Zhang M, Wang Z, Gao X, Li M
The Journal of nutritional biochemistry 2021 Nov 27;101:108924
The Journal of nutritional biochemistry 2021 Nov 27;101:108924
Porcine TRIM21 RING-finger E3 ubiquitin ligase is essential for anti-PRRSV activity.
Wei Y, Zeng S, Zou C, Zhang H, Peng O, Xue C, Cao Y
Veterinary microbiology 2021 May;256:109043
Veterinary microbiology 2021 May;256:109043
Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein.
Hsu JC, Laurent-Rolle M, Pawlak JB, Wilen CB, Cresswell P
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 15;118(24)
Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting.
Jin J, Meng X, Huo Y, Deng H
Cell death & disease 2021 Jul 13;12(7):697
Cell death & disease 2021 Jul 13;12(7):697
Upregulated E3 ligase tripartite motif-containing protein 21 in psoriatic epidermis ubiquitylates nuclear factor-κB p65 subunit and promotes inflammation in keratinocytes.
Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G
The British journal of dermatology 2021 Jan;184(1):111-122
The British journal of dermatology 2021 Jan;184(1):111-122
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling.
Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K, Yu VC
EMBO reports 2021 Jan 7;22(1):e50854
EMBO reports 2021 Jan 7;22(1):e50854
Ectopic Expression of TRIM25 Restores RIG-I Expression and IFN Production Reduced by Multiple Enteroviruses 3Cpro.
Xiao H, Li J, Yang X, Li Z, Wang Y, Rui Y, Liu B, Zhang W
Virologica Sinica 2021 Dec;36(6):1363-1374
Virologica Sinica 2021 Dec;36(6):1363-1374
UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.
Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W
EMBO reports 2020 Jan 7;21(1):e47528
EMBO reports 2020 Jan 7;21(1):e47528
TRIM21-SERPINB5 aids GMPS repression to protect nasopharyngeal carcinoma cells from radiation-induced apoptosis.
Zhang P, Li X, He Q, Zhang L, Song K, Yang X, He Q, Wang Y, Hong X, Ma J, Liu N
Journal of biomedical science 2020 Jan 31;27(1):30
Journal of biomedical science 2020 Jan 31;27(1):30
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma.
Liu XF, Tang CX, Zhang L, Tong SY, Wang Y, Abdulrahman AA, Ji GQ, Gao Y, Gao DS, Zhang BL
Neurochemical research 2020 Dec;45(12):2915-2925
Neurochemical research 2020 Dec;45(12):2915-2925
Enhanced T-cell proliferation and IL-6 secretion mediated by overexpression of TRIM21 in oral lesions of patients with oral lichen planus.
Wei W, Wang Y, Sun Q, Jiang C, Zhu M, Song C, Li C, Du G, Deng Y, Nie H, Tang G
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2020 Apr;49(4):350-356
TRIM21 Mitigates Human Lung Microvascular Endothelial Cells' Inflammatory Responses to LPS.
Li L, Wei J, Mallampalli RK, Zhao Y, Zhao J
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
American journal of respiratory cell and molecular biology 2019 Dec;61(6):776-785
Enhancement of Th1/Th17 inflammation by TRIM21 in Behçet's disease.
Ahn Y, Hwang JH, Zheng Z, Bang D, Kim DY
Scientific reports 2017 Jun 7;7(1):3018
Scientific reports 2017 Jun 7;7(1):3018
Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism.
Fan W, Zhang D, Qian P, Qian S, Wu M, Chen H, Li X
Antiviral research 2016 Mar;127:32-40
Antiviral research 2016 Mar;127:32-40
Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.
Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
The Journal of biological chemistry 2015 Nov 20;290(47):28428-28437
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 12108-1-AP(TRIM21 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM21 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM21. This antibody recognizes human, mouse, rat antigen. The TRIM21 antibody has been validated for the following applications: ELISA, WB, IHC analysis.