Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Immunohistochemistry [4]
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- Product number
- NBP1-89300 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-89300, RRID:AB_11048555
- Product name
- Rabbit Polyclonal FLNC Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human FLNC antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references BAG3P215L/KO Mice as a Model of BAG3P209L Myofibrillar Myopathy.
De novo mutations in FLNC leading to early-onset restrictive cardiomyopathy and congenital myopathy.
HSPB7 is indispensable for heart development by modulating actin filament assembly.
Congenital dilated cardiomyopathy caused by biallelic mutations in Filamin C.
Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy.
Robertson R, Conte TC, Dicaire MJ, Rymar VV, Sadikot AF, Bryson-Richardson RJ, Lavoie JN, O'Ferrall E, Young JC, Brais B
The American journal of pathology 2020 Mar;190(3):554-562
The American journal of pathology 2020 Mar;190(3):554-562
De novo mutations in FLNC leading to early-onset restrictive cardiomyopathy and congenital myopathy.
Kiselev A, Vaz R, Knyazeva A, Khudiakov A, Tarnovskaya S, Liu J, Sergushichev A, Kazakov S, Frishman D, Smolina N, Pervunina T, Jorholt J, Sjoberg G, Vershinina T, Rudenko D, Arner A, Sejersen T, Lindstrand A, Kostareva A
Human mutation 2018 Sep;39(9):1161-1172
Human mutation 2018 Sep;39(9):1161-1172
HSPB7 is indispensable for heart development by modulating actin filament assembly.
Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):11956-11961
Proceedings of the National Academy of Sciences of the United States of America 2017 Nov 7;114(45):11956-11961
Congenital dilated cardiomyopathy caused by biallelic mutations in Filamin C.
Reinstein E, Gutierrez-Fernandez A, Tzur S, Bormans C, Marcu S, Tayeb-Fligelman E, Vinkler C, Raas-Rothschild A, Irge D, Landau M, Shohat M, Puente XS, Behar DM, Lopez-Otın C
European journal of human genetics : EJHG 2016 Dec;24(12):1792-1796
European journal of human genetics : EJHG 2016 Dec;24(12):1792-1796
Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy.
Valdés-Mas R, Gutiérrez-Fernández A, Gómez J, Coto E, Astudillo A, Puente DA, Reguero JR, Álvarez V, Morís C, León D, Martín M, Puente XS, López-Otín C
Nature communications 2014 Oct 29;5:5326
Nature communications 2014 Oct 29;5:5326
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: FLNC Antibody [NBP1-89300] - Staining of human skeletal muscle shows high expression.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: FLNC Antibody [NBP1-89300] - Staining of human skin shows low expression as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: FLNC Antibody [NBP1-89300] - Analysis in human skeletal muscle and liver tissues. Corresponding FLNC RNA-seq data are presented for the same tissues.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: FLNC Antibody [NBP1-89300] - Staining of human liver shows no positivity in hepatocytes as expected.