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GSAP
Gamma-secretase activating proteinLOC54103, PION
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]). [supplied by OMIM, Nov 2010]
Top validated antibodies |
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| LSBio |  LS-C144312 |
Polyclonal |
WB
EL
ICC
IHC
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| GeneTex | GTX32001 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-21092 |
1 references | Polyclonal |
WB
ICC
IHC
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| Boster Biological Technology | A09313 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN954149 |
2 references | Polyclonal |
WB
IHC
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