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Protein structure
BIRC7
Baculoviral IAP repeat containing 7KIAP, ML-IAP, mliap, RNF50
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
Top validated antibodies |
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| antibodies-online |  ABIN252145 |
5 references | Polyclonal |
WB
IP
IHC
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| GeneTex | GTX31663 |
Polyclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | NB100-56548 |
22 references | Monoclonal |
WB
ICC
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| Proteintech Group | 27543-1-AP |
3 references | Polyclonal |
WB
EL
IHC
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| Boster Biological Technology | A02577 |
Polyclonal |
WB
EL
ICC
IHC
|
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