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- Antibody Data
- Antigen structure
- References [78]
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- Western blot [3]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 16225-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16225-1-AP, RRID:AB_2143977
- Product name
- MCL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCL1 antibody (Cat. #16225-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Loss of miR-1469 expression mediates melanoma cell migration and invasion.
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.
The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
CircPVT1 promotes gallbladder cancer growth by sponging miR-339-3p and regulates MCL-1 expression.
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells.
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Ixazomib inhibits myeloma cell proliferation by targeting UBE2K.
Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling.
Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy.
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy.
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.
Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer.
Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.
SRT2183 impairs ovarian cancer by facilitating autophagy.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
ALG-2 couples T cell activation and apoptosis by regulating proteasome activity and influencing MCL1 stability.
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.
IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation.
Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer.
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells.
EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway.
MCL-1 is a prognostic indicator and drug target in breast cancer.
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells.
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.
Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.
Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer.
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways.
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
A caspase-dependent pathway is involved in Wnt/β-catenin signaling promoted apoptosis in Bacillus Calmette-Guerin infected RAW264.7 macrophages.
Revisiting the role of MCL1 in tumorigenesis of solid cancer: gene expression correlates with antiproliferative phenotype in breast cancer cells and its functional regulatory variants are associated with reduced cancer susceptibility.
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor.
Liu F, Zhao Q, Su Y, Lv J, Gai Y, Liu S, Lin H, Wang Y, Wang G
Experimental hematology 2022 Jan;105:39-49
Experimental hematology 2022 Jan;105:39-49
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Yang W, Feng Q, Li M, Su J, Wang P, Wang X, Yin Y, Wang X, Zhao M
Frontiers in molecular biosciences 2021;8:684262
Frontiers in molecular biosciences 2021;8:684262
Loss of miR-1469 expression mediates melanoma cell migration and invasion.
DiVincenzo MJ, Barricklow Z, Schwarz E, Moufawad M, Howard JH, Yu L, Chung C, Gru AA, Carson WE 3rd
PloS one 2021;16(9):e0256629
PloS one 2021;16(9):e0256629
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease.
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X
Nature communications 2021 Sep 6;12(1):5305
Nature communications 2021 Sep 6;12(1):5305
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Sun L, Jiang Y, Yan X, Dai X, Huang C, Chen L, Li T, Zhang Y, Xiao H, Yang M, Xiang L, Zhang Y, Chen S, Li S, Chen A, He F, Lian J
Experimental cell research 2021 Sep 1;406(1):112755
Experimental cell research 2021 Sep 1;406(1):112755
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.
Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H
Cell reports 2021 Nov 9;37(6):109988
Cell reports 2021 Nov 9;37(6):109988
The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
Li X, Su Y, Hege K, Madlambayan G, Edwards H, Knight T, Polin L, Kushner J, Dzinic SH, White K, Yang J, Miller R, Wang G, Zhao L, Wang Y, Lin H, Taub JW, Ge Y
Haematologica 2021 May 1;106(5):1262-1277
Haematologica 2021 May 1;106(5):1262-1277
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Qiao X, Ma J, Knight T, Su Y, Edwards H, Polin L, Li J, Kushner J, Dzinic SH, White K, Wang J, Lin H, Wang Y, Wang L, Wang G, Taub JW, Ge Y
Blood cancer journal 2021 Jun 7;11(6):111
Blood cancer journal 2021 Jun 7;11(6):111
CircPVT1 promotes gallbladder cancer growth by sponging miR-339-3p and regulates MCL-1 expression.
Wang S, Su TT, Tong H, Shi W, Ma F, Quan Z
Cell death discovery 2021 Jul 26;7(1):191
Cell death discovery 2021 Jul 26;7(1):191
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Xu Y, Yu J, Ma C, Gong Z, Wu X, Deng G
Molecular immunology 2021 Feb;130:85-95
Molecular immunology 2021 Feb;130:85-95
Ezrin Promotes the Proliferation, Migration, and Invasion of Ovarian Cancer Cells.
Li MJ, Xiong D, Huang H, Wen ZY
Biomedical and environmental sciences : BES 2021 Feb 20;34(2):139-151
Biomedical and environmental sciences : BES 2021 Feb 20;34(2):139-151
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Chang L, Zhou R, He Y, Meng M, Hu J, Liu Y, Pan Y, Tang Z, Yue Z
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Ixazomib inhibits myeloma cell proliferation by targeting UBE2K.
Wang Q, Dong Z, Su J, Huang J, Xiao P, Tian L, Chen Y, Ma L, Chen X
Biochemical and biophysical research communications 2021 Apr 16;549:1-7
Biochemical and biophysical research communications 2021 Apr 16;549:1-7
Pharmaceutical Drug Metformin and MCL1 Inhibitor S63845 Exhibit Anticancer Activity in Myeloid Leukemia Cells via Redox Remodeling.
Valiulienė G, Vitkevičienė A, Skliutė G, Borutinskaitė V, Navakauskienė R
Molecules (Basel, Switzerland) 2021 Apr 15;26(8)
Molecules (Basel, Switzerland) 2021 Apr 15;26(8)
Chaetomugilin J Enhances Apoptosis in Human Ovarian Cancer A2780 Cells Induced by Cisplatin Through Inhibiting Pink1/Parkin Mediated Mitophagy.
Hu X, Wang J, Chai J, Yu X, Zhang Y, Feng Y, Qin J, Yu H
OncoTargets and therapy 2020;13:9967-9976
OncoTargets and therapy 2020;13:9967-9976
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Huang G, Chen J, Liu J, Zhang X, Duan H, Fang Q
OncoTargets and therapy 2020;13:10817-10828
OncoTargets and therapy 2020;13:10817-10828
Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.
Shan L, Liu W, Zhan Y
Frontiers in oncology 2020;10:516552
Frontiers in oncology 2020;10:516552
ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.
Li YL, Wu LW, Zeng LH, Zhang ZY, Wang W, Zhang C, Lin NM
Oncogene 2020 Sep;39(39):6203-6217
Oncogene 2020 Sep;39(39):6203-6217
Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy.
Hu X, Xia M, Wang J, Yu H, Chai J, Zhang Z, Sun Y, Su J, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110397
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110397
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)
International journal of molecular sciences 2020 Sep 12;21(18)
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.
Munkhbaatar E, Dietzen M, Agrawal D, Anton M, Jesinghaus M, Boxberg M, Pfarr N, Bidola P, Uhrig S, Höckendorf U, Meinhardt AL, Wahida A, Heid I, Braren R, Mishra R, Warth A, Muley T, Poh PSP, Wang X, Fröhling S, Steiger K, Slotta-Huspenina J, van Griensven M, Pfeiffer F, Lange S, Rad R, Spella M, Stathopoulos GT, Ruland J, Bassermann F, Weichert W, Strasser A, Branca C, Heikenwalder M, Swanton C, McGranahan N, Jost PJ
Nature communications 2020 Sep 10;11(1):4527
Nature communications 2020 Sep 10;11(1):4527
Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7-MCL1 axis in gastric cancer.
Li C, Deng C, Pan G, Wang X, Zhang K, Dong Z, Zhao G, Tan M, Hu X, Shi S, Du J, Ji H, Wang X, Yang L, Cui H
Journal of experimental & clinical cancer research : CR 2020 Oct 30;39(1):230
Journal of experimental & clinical cancer research : CR 2020 Oct 30;39(1):230
Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation.
Nagareddy B, Khan A, Kim H
The Journal of biological chemistry 2020 Oct 2;295(40):13887-13901
The Journal of biological chemistry 2020 Oct 2;295(40):13887-13901
SRT2183 impairs ovarian cancer by facilitating autophagy.
Sun T, Hu Y, He W, Shang Y, Yang X, Gong L, Zhang X, Gong P, Yang G
Aging 2020 Nov 20;12(23):24208-24218
Aging 2020 Nov 20;12(23):24208-24218
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
Hu C, Xia H, Bai S, Zhao J, Edwards H, Li X, Yang Y, Lyu J, Wang G, Zhan Y, Dong Y, Ge Y
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
ALG-2 couples T cell activation and apoptosis by regulating proteasome activity and influencing MCL1 stability.
He TS, Ji W, Zhang J, Lu J, Liu X
Cell death & disease 2020 Jan 2;11(1):5
Cell death & disease 2020 Jan 2;11(1):5
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
Jiang W, Wu Y, He T, Zhu H, Ke G, Xiang L, Yang H
Molecular cancer therapeutics 2020 Feb;19(2):337-347
Molecular cancer therapeutics 2020 Feb;19(2):337-347
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J
Life sciences 2020 Aug 1;254:116444
Life sciences 2020 Aug 1;254:116444
The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein.
Wu L, Lin Y, Feng J, Qi Y, Wang X, Lin Q, Shi W, Zheng E, Wang W, Hou Z, Lin H, Yu C, He Y, Xu Y, Yang H, Lin L, Li L
Cancer cell international 2019;19:222
Cancer cell international 2019;19:222
The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.
Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, Jin X, Gao Y, Wu Y, Cao Y, Zhang Y, Xi L, Wang S, Hu J, Ma D, Zhou J, Gao Q, Chen G
EBioMedicine 2019 Nov;49:26-39
EBioMedicine 2019 Nov;49:26-39
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Acetyl-11-keto-β-boswellic acid suppresses docetaxel-resistant prostate cancer cells in vitro and in vivo by blocking Akt and Stat3 signaling, thus suppressing chemoresistant stem cell-like properties.
Liu YQ, Wang SK, Xu QQ, Yuan HQ, Guo YX, Wang Q, Kong F, Lin ZM, Sun DQ, Wang RM, Lou HX
Acta pharmacologica Sinica 2019 May;40(5):689-698
Acta pharmacologica Sinica 2019 May;40(5):689-698
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X, Zhao M
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Liu F, Knight T, Su Y, Edwards H, Wang G, Wang Y, Taub JW, Lin H, Sun L, Ge Y
Targeted oncology 2019 Jun;14(3):351-364
Targeted oncology 2019 Jun;14(3):351-364
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chen L, Liu L, Xie ZY, Wang F, Zhu L, Zhang C, Fan P, Sinkemani A, Hong X, Wu XT
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Xie L, Li M, Liu D, Wang X, Wang P, Dai H, Yang W, Liu W, Hu X, Zhao M
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck.
Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, Cohen GM, Varadarajan S
Cell death & disease 2019 Dec 4;10(12):912
Cell death & disease 2019 Dec 4;10(12):912
IFN-β is a macrophage-derived effector cytokine facilitating the resolution of bacterial inflammation.
Kumaran Satyanarayanan S, El Kebir D, Soboh S, Butenko S, Sekheri M, Saadi J, Peled N, Assi S, Othman A, Schif-Zuck S, Feuermann Y, Barkan D, Sher N, Filep JG, Ariel A
Nature communications 2019 Aug 2;10(1):3471
Nature communications 2019 Aug 2;10(1):3471
Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer.
Chen L, Cheng CS, Gao H, Zhan L, Wang F, Qu C, Li Y, Wang P, Chen H, Meng Z, Liu L, Chen H, Chen Z
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7343090
Evidence-based complementary and alternative medicine : eCAM 2018;2018:7343090
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585
International journal of biological sciences 2018;14(5):577-585
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Wang X, Liu W, Wang P, Li S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
A Non-apoptotic Function of MCL-1 in Promoting Pluripotency and Modulating Mitochondrial Dynamics in Stem Cells.
Rasmussen ML, Kline LA, Park KP, Ortolano NA, Romero-Morales AI, Anthony CC, Beckermann KE, Gama V
Stem cell reports 2018 Mar 13;10(3):684-692
Stem cell reports 2018 Mar 13;10(3):684-692
EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway.
Huang R, Liu H, Chen Y, He Y, Kang Q, Tu S, He Y, Zhou X, Wang L, Yang J, Wu A, Li Y
Oncology reports 2018 Jan;39(1):119-128
Oncology reports 2018 Jan;39(1):119-128
MCL-1 is a prognostic indicator and drug target in breast cancer.
Campbell KJ, Dhayade S, Ferrari N, Sims AH, Johnson E, Mason SM, Dickson A, Ryan KM, Kalna G, Edwards J, Tait SWG, Blyth K
Cell death & disease 2018 Jan 16;9(2):19
Cell death & disease 2018 Jan 16;9(2):19
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Su Y, Li X, Ma J, Zhao J, Liu S, Wang G, Edwards H, Taub JW, Lin H, Ge Y
Biochemical pharmacology 2018 Feb;148:13-26
Biochemical pharmacology 2018 Feb;148:13-26
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X, Jiang C
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells.
Zhao Y, He J, Li J, Peng X, Wang X, Dong Z, Zhao E, Liu Y, Wu Z, Cui H
Cell death & disease 2017 Oct 26;8(10):e3133
Cell death & disease 2017 Oct 26;8(10):e3133
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
Gao C, Sun R, Xie YR, Jiang AL, Lin M, Li M, Chen ZW, Zhang P, Jin H, Feng JP
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.
Zheng M, Xu H, Liao XH, Chen CP, Zhang AL, Lu W, Wang L, Yang D, Wang J, Liu H, Zhou XZ, Lu KP
Oncotarget 2017 May 2;8(18):29771-29784
Oncotarget 2017 May 2;8(18):29771-29784
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation.
Lu L, Zhang S, Li C, Zhou C, Li D, Liu P, Huang M, Shen X
Cell death & disease 2017 May 11;8(5):e2767
Cell death & disease 2017 May 11;8(5):e2767
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866
Nature communications 2017 Mar 31;8:14866
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy.
Feng T, Cao W, Shen W, Zhang L, Gu X, Guo Y, Tsai HI, Liu X, Li J, Zhang J, Li S, Wu F, Liu Y
Oncotarget 2017 Jan 3;8(1):329-344
Oncotarget 2017 Jan 3;8(1):329-344
Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation.
Yao S, Xu F, Chen Y, Ge Y, Zhang F, Huang H, Li L, Lin D, Luo X, Xu J, Luo D, Zhu X, Liu Y
Journal of experimental & clinical cancer research : CR 2017 Jan 10;36(1):10
Journal of experimental & clinical cancer research : CR 2017 Jan 10;36(1):10
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, Zhu B, Feng X, Shi J, Li J, Xia X, Jia W, Chen J, Chen Y, Jiang X
Oncology letters 2017 Feb;13(2):921-929
Oncology letters 2017 Feb;13(2):921-929
Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.
Li C, Miao R, Liu S, Wan Y, Zhang S, Deng Y, Bi J, Qu K, Zhang J, Liu C
Oncotarget 2017 Apr 25;8(17):28683-28695
Oncotarget 2017 Apr 25;8(17):28683-28695
Francisella tularensis Modulates a Distinct Subset of Regulatory Factors and Sustains Mitochondrial Integrity to Impair Human Neutrophil Apoptosis.
McCracken JM, Kinkead LC, McCaffrey RL, Allen LA
Journal of innate immunity 2016;8(3):299-313
Journal of innate immunity 2016;8(3):299-313
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer.
Wang SH, Zhang WJ, Wu XC, Weng MZ, Zhang MD, Cai Q, Zhou D, Wang JD, Quan ZW
Journal of cellular and molecular medicine 2016 Dec;20(12):2299-2308
Journal of cellular and molecular medicine 2016 Dec;20(12):2299-2308
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Zhao S, Li H, Jiang C, Ma T, Wu C, Huo Q, Liu H
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Dai B, Wang W, Liu R, Wang H, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways.
Wu KN, Zhao YM, He Y, Wang BS, Du KL, Fu S, Hu KM, Zhang LF, Liu LZ, Hu YX, Wang YJ, Huang H
Leukemia & lymphoma 2014 Mar;55(3):668-76
Leukemia & lymphoma 2014 Mar;55(3):668-76
Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.
Zhang Q, Zhang Y, Zhang P, Chao Z, Xia F, Jiang C, Zhang X, Jiang Z, Liu H
Genes & cancer 2014 Mar;5(3-4):100-12
Genes & cancer 2014 Mar;5(3-4):100-12
A caspase-dependent pathway is involved in Wnt/β-catenin signaling promoted apoptosis in Bacillus Calmette-Guerin infected RAW264.7 macrophages.
Wu X, Deng G, Hao X, Li Y, Zeng J, Ma C, He Y, Liu X, Wang Y
International journal of molecular sciences 2014 Mar 21;15(3):5045-62
International journal of molecular sciences 2014 Mar 21;15(3):5045-62
Revisiting the role of MCL1 in tumorigenesis of solid cancer: gene expression correlates with antiproliferative phenotype in breast cancer cells and its functional regulatory variants are associated with reduced cancer susceptibility.
Wang S, Jiang Y, Liu J, Zhao Y, Xiang C, Ma R, Gao H, Jin L, He F, Wang H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Aug;35(8):8289-99
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Aug;35(8):8289-99
Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli.
Yu G, Jiang L, Xu Y, Guo H, Liu H, Zhang Y, Yang H, Yuan C, Ma J
PloS one 2012;7(11):e48146
PloS one 2012;7(11):e48146
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
Gong K, Chen C, Zhan Y, Chen Y, Huang Z, Li W
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Xu H, Jiang B, Meng L, Ren T, Zeng Y, Wu J, Qu L, Shou C
Carcinogenesis 2012 Jun;33(6):1193-202
Carcinogenesis 2012 Jun;33(6):1193-202
Functional regulatory variants of MCL1 contribute to enhanced promoter activity and reduced risk of lung cancer in nonsmokers: implications for context-dependent phenotype of an antiapoptotic and antiproliferative gene in solid tumor.
Jiang Y, Wang W, Wang J, Lu Y, Chen Y, Jin L, Lin D, He F, Wang H
Cancer 2012 Apr 15;118(8):2085-95
Cancer 2012 Apr 15;118(8):2085-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 16225-1-AP(MCL1 antibody) at dilution of 1:500
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Raji cells were subjected to SDS PAGE followed by western blot with 16225-1-AP(MCL1 antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse spleen tissue were subjected to SDS PAGE followed by western blot with 16225-1-AP(MCL1 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-MCL1 (IP:16225-1-AP, 3ug; Detection:16225-1-AP 1:1000) with Raji cells lysate 800ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MCL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCL1. This antibody recognizes human,mouse,rat antigen. The MCL1 antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.
