CABT-RM158

antibody from Creative Diagnostics

Targeting: SLC18A1 CGAT, VAT1, VMAT1

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-RM158

Provider

Creative Diagnostics

Product name

Mouse Anti-SLC18A1 monoclonal antibody, clone O550/32

Antibody type

Monoclonal

Description

Chromaffin granule amine transporter is encoded by the Scl19a1 gene in murine species. Vesicular monoamine transporters (VMATs) are involved in presynaptic storage and release of neurotransmitters. They are located in the presynaptic region and are involved in the transport of monoamines into storage vesicle, which are released upon arrival of an action potential. Two structurally related, but pharmacologically distinct, VMATs have been described (VMAT1 and VMAT2) that are encoded by separate genes. VMAT1 is a multi-pass membrane acidic glycoprotein that is found in both large dense-core vesicles and in small synaptic vesicles. It s both C- and N-terminal regions are located in the cytosolic side of the vesicle. VMAT1 is detected in adrenal medulla, and brain (at protein level). In brain, specifically found in the medulla oblongata, pons, prefrontal cortex, striatum, dentate gyrus and hippocampus. VMAT1 is shown to play a key role in survival of hippocampal neurons and may contribute to neurocognitive deficits observed in neuropsychiatric disorders.

Reactivity

Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG