H00000684-B02P

Nehls J, Businger R, Hoffmann M, Brinkmann C, Fehrenbacher B, Schaller M, Maurer B, Schönfeld C, Kramer D, Hailfinger S, Pöhlmann S, Schindler M
Cell reports 2019 Feb 12;26(7):1841-1853.e6

Overweight in elderly people induces impaired autophagy in skeletal muscle.

Potes Y, de Luxán-Delgado B, Rodriguez-González S, Guimarães MRM, Solano JJ, Fernández-Fernández M, Bermúdez M, Boga JA, Vega-Naredo I, Coto-Montes A
Free radical biology & medicine 2017 Sep;110:31-41

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain.

Mack K, Starz K, Sauter D, Langer S, Bibollet-Ruche F, Learn GH, Stürzel CM, Leoz M, Plantier JC, Geyer M, Hahn BH, Kirchhoff F
Journal of virology 2017 Mar 15;91(6)

Tetherin is an exosomal tether.

Edgar JR, Manna PT, Nishimura S, Banting G, Robinson MS
eLife 2016 Sep 22;5

The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies.

Brinkmann C, Nehlmeier I, Walendy-Gnirß K, Nehls J, González Hernández M, Hoffmann M, Qiu X, Takada A, Schindler M, Pöhlmann S
Journal of virology 2016 Dec 15;90(24):11075-11086

Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.

Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F
Cell host & microbe 2016 Apr 13;19(4):504-14

Lack of adaptation to human tetherin in HIV-1 group O and P.

Yang SJ, Lopez LA, Exline CM, Haworth KG, Cannon PM
Retrovirology 2011 Sep 28;8:78

Tethered virions are intermediates in the assembly and release of HIV-1 particles.

Karetnikov A, Suomalainen M
Virology 2010 Nov 25;407(2):289-95

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment.

Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli JC, Cannon PM
Retrovirology 2010 Jun 7;7:51

Tetherin restricts productive HIV-1 cell-to-cell transmission.

Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O
PLoS pathogens 2010 Jun 17;6(6):e1000955

Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal.

Lopez LA, Yang SJ, Hauser H, Exline CM, Haworth KG, Oldenburg J, Cannon PM
Journal of virology 2010 Jul;84(14):7243-55

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration.

Gupta RK, Mlcochova P, Pelchen-Matthews A, Petit SJ, Mattiuzzo G, Pillay D, Takeuchi Y, Marsh M, Towers GJ
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 8;106(49):20889-94

HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes.

Iwabu Y, Fujita H, Kinomoto M, Kaneko K, Ishizaka Y, Tanaka Y, Sata T, Tokunaga K
The Journal of biological chemistry 2009 Dec 11;284(50):35060-72

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BST2 Antibody [H00000684-B02P] - analysis of BST2 expression in transfected 293T cell line by BST2 MaxPab polyclonal antibody. Lane 1: BST2 transfected lysate (19.8 KDa). Lane 2: Non-transfected lysate.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BST2 Antibody [H00000684-B02P] - Analysis of BST2 expression in transfected 293T cell line by BST2 polyclonal antibody. Lane 1: BST2 transfected lysate(19.8 KDa). Lane 2: Non-transfected lysate.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BST2 Antibody [H00000684-B02P] - Analysis of BST2 expression in human spleen.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: BST2 Antibody [H00000684-B02P] - Analysis of BST2 expression in Jurkat.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunocytochemistry/Immunofluorescence: BST2 Antibody [H00000684-B02P] - Analysis of purified antibody to BST2 on HeLa cell. (antibody concentration 10 ug/ml)

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Immunohistochemistry-Paraffin: BST2 Antibody [H00000684-B02P] - Analysis of purified antibody to BST2 on formalin-fixed paraffin-embedded human kidney. (antibody concentration 3 ug/ml)