348402

antibody from BioLegend
Targeting: BST2 CD317, tetherin
Provider product page for 348402

Antibody data

Product number
348402 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#348402, RRID:AB_10588013
Product name
Purified anti-human CD317 (BST2, Tetherin)
Antibody type
Monoclonal
Antigen
CD317
Description
CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.
Reactivity
Human, Simian
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
BST2 protein structure - 348402 shown in red.