BS5871

antibody from Bioworld Technology, Inc
Targeting: PTPRN2 IA-2beta, ICAAR, KIAA0387, phogrin
Provider product page for BS5871

Antibody data

Product number
BS5871 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PTPRN2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 248-293 of Human PTPRN2.
Description
Protein-Tyrosine Phosphatase Receptor-Type IA-2ÉÇ (PTP IA-2ÉÇ), alternately known as PTPRN2 or Phogrin, localizes in dense-core secretory vesicles of pancreas islet cells and influences insulin secretion. The PTP IA-2ÉÇ precursor is an autoantigen that contributes to insulin-dependent diabetes mellitus (IDDM). The autoantigenic epitopes of PTP IA-2ÉÇ appear within the cytoplasmic domain of this transmembrane protein. PTP IA-2ÉÇ is present at high levels in brain and pancreas with lower levels in trachea, prostate, stomach and spinal cord. The human PTPRN2 gene maps to chromosome 7q36. Northern blot analysis showed that PTPRN2 was expressed as 5.5- and 3.7-kb transcripts primarily in human brain and pancreas. Three alternative transcript splice variants of this gene encode distinct proteins.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PTPRN2 protein structure - BS5871 shown in red.