CABT-B8599

antibody from Creative Diagnostics

Targeting: SLFN11 FLJ34922

No application information provided.

Antibody Data

Product number

CABT-B8599

Provider

Creative Diagnostics

Product name

Anti-SLFN11 monoclonal antibody, clone 5H0

Antibody type

Monoclonal

Description

SLFN11 (schlafen family member 11) is a protein-coding gene. Diseases associated with SLFN11 include melanoma. GO annotations related to this gene include tRNA binding and ATP binding. An important paralog of this gene is SLFN13. Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. 0The function about SLFN11 antigen include ATP binding