FHOD1

This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Formin homology 2 domain containing 1

Tissue specificity

Tissue enhanced (lymphoid tissue, skeletal muscle)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (67229387 - 67247481)

Ensembl ID

ENSG00000135723  (ver. 103.38)

Orthologs

Mouse Fhod1: ENSMUSG00000014778

UniProt

Q9Y613

neXtProt

NX_Q9Y613

Human splice variants
Mouse splice variants

Protein structure