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IDH2
Isocitrate dehydrogenase (NADP(+)) 2Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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| Proteintech Group |  15932-1-AP |
45 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C346272 |
Polyclonal |
WB
ICC
IP
IHC
ChIP
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| Invitrogen Antibodies | PA5-96605 |
Polyclonal |
WB
ICC
IP
IHC
ChIP
OA
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| Novus Biologicals | H00003418-M01 |
4 references | Monoclonal |
WB
EL
IHC
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| Boster Biological Technology | PB9602 |
2 references | Polyclonal |
WB
ICC
IHC
FC
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