PON3

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

Description

Paraoxonase 3

Tissue specificity

Tissue enriched (liver)

Predicted location

Secreted to blood

Protein family

Candidate cardiovascular disease genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (95359872 - 95396375)

Ensembl ID

ENSG00000105852  (ver. 103.38)

Orthologs

Mouse Pon3: ENSMUSG00000029759

UniProt

Q15166

neXtProt

NX_Q15166

Human splice variants
Mouse splice variants

Protein structure