Tissue expression
Cell line expression
Protein structure
MUS81
MUS81 structure-specific endonuclease subunitFLJ44872, SLX3
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]
Top validated antibodies |
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Novus Biologicals | NB100-2064 | 2 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
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Proteintech Group | 11018-1-AP | 2 references | Polyclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN151532 | 2 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
|
GeneTex | GTX80370 | Monoclonal |
WB
ICC
IP
FC |
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NovoPro Bioscience Inc. | 112900 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider