SLC7A11

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Description

Solute carrier family 7 member 11

Tissue specificity

Tissue enhanced (brain)

Subcell location

Vesicles

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

4 (138164097 - 138242349)

Ensembl ID

ENSG00000151012  (ver. 103.38)

Orthologs

Mouse Slc7a11: ENSMUSG00000027737

UniProt

Q9UPY5

neXtProt

NX_Q9UPY5

Human splice variants
Mouse splice variants

Protein structure