PCSK4

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]

Description

Proprotein convertase subtilisin/kexin type 4

Tissue specificity

Tissue enriched (testis)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

19 (1481428 - 1490752)

Ensembl ID

ENSG00000115257  (ver. 103.38)

Orthologs

Mouse Pcsk4: ENSMUSG00000020131

UniProt

Q6UW60

neXtProt

NX_Q6UW60

Human splice variants
Mouse splice variants

Protein structure