Tissue expression
Cell line expression
Protein structure
DENND1A
DENN domain containing 1AFAM31A, FLJ21129, KIAA1608
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). [supplied by OMIM, Nov 2010]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
Polyclonal |
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antibodies-online | ![]() |
2 references | Polyclonal |
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Proteintech Group | ![]() |
Polyclonal |
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NovoPro Bioscience Inc. | ![]() |
Polyclonal |
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Aviva Systems Biology | ![]() |
Polyclonal |
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