Tissue expression
Cell line expression
Protein structure
PCBP1
Poly(rC) binding protein 1hnRNP-E1, hnRNP-X, HNRPE1, HNRPX
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Novus Biologicals | H00005093-M01 | 5 references | Monoclonal |
WB
EL
ICC
|
|
Proteintech Group | 14523-1-AP | 10 references | Polyclonal |
WB
EL
IHC
|
|
Boster Biological Technology | A02636-1 | 1 references | Polyclonal |
WB
EL
IHC
FC |
|
antibodies-online | ABIN518653 | 1 references | Monoclonal |
WB
EL
ICC
|
|
LSBio | LS-C197850 | Monoclonal |
WB
EL
ICC
|
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