ZNF382

This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Description

Zinc finger protein 382

Tissue specificity

Tissue enhanced (brain, retina)

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

19 (36604817 - 36634114)

Ensembl ID

ENSG00000161298  (ver. 103.38)

Orthologs

Mouse Zfp382: ENSMUSG00000074220

UniProt

Q96SR6

neXtProt

NX_Q96SR6

Human splice variants
Mouse splice variants

Protein structure