Antibody data
- Antibody Data
- Antigen structure
- References [35]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10694-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10694-1-AP, RRID:AB_2297252
- Product name
- TIP47 antibody
- Antibody type
- Polyclonal
- Description
- TIP47 antibody (Cat. #10694-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Fatty acyl-coenzyme A activates mitochondrial division through oligomerization of MiD49 and MiD51.
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells.
Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression.
Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.
Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies.
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.
Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice.
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL.
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.
Multiplex fatty acid imaging inside cells by Raman microscopy.
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.
Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.
Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.
Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240.
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.
CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.
HCV core residues critical for infectivity are also involved in core-NS5A complex formation.
Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte.
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.
Liu A, Kage F, Abdulkareem AF, Aguirre-Huamani MP, Sapp G, Aydin H, Higgs HN
Nature cell biology 2024 May;26(5):731-744
Nature cell biology 2024 May;26(5):731-744
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease.
Du J, Ji X, Xu B, Du Q, Li Y, Zhou B, Liu X, Xu Z, Jiang Y, Kou B, Li Z, Cui C, Lin J
Metabolism: clinical and experimental 2024 Mar;152:155769
Metabolism: clinical and experimental 2024 Mar;152:155769
The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells.
Schempp R, Eilts J, Schöl M, Grijalva Yépez MF, Fekete A, Wigger D, Schumacher F, Kleuser B, van Ham M, Jänsch L, Sauer M, Avota E
International journal of molecular sciences 2024 Mar 13;25(6)
International journal of molecular sciences 2024 Mar 13;25(6)
Tumor-derived Prevotella intermedia aggravates gastric cancer by enhancing Perilipin 3 expression.
Liang W, Zhou Z, Gao Q, Zhu Z, Zhu J, Lin J, Wen Y, Qian F, Wang L, Zhai Y, Lv J, Zhang H, Zhong F, Du H
Cancer science 2024 Apr;115(4):1141-1153
Cancer science 2024 Apr;115(4):1141-1153
Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.
Gahlot P, Kravic B, Rota G, van den Boom J, Levantovsky S, Schulze N, Maspero E, Polo S, Behrends C, Meyer H
Molecular cell 2024 Apr 18;84(8):1556-1569.e10
Molecular cell 2024 Apr 18;84(8):1556-1569.e10
Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.
Roberts MA, Deol KK, Mathiowetz AJ, Lange M, Leto DE, Stevenson J, Hashemi SH, Morgens DW, Easter E, Heydari K, Nalls MA, Bassik MC, Kampmann M, Kopito RR, Faghri F, Olzmann JA
Developmental cell 2023 Sep 25;58(18):1782-1800.e10
Developmental cell 2023 Sep 25;58(18):1782-1800.e10
The endo-lysosomal regulatory protein BLOC1S1 modulates hepatic lysosomal content and lysosomal lipolysis.
Wu K, Zou J, Sack MN
Biochemical and biophysical research communications 2023 Jan 29;642:1-10
Biochemical and biophysical research communications 2023 Jan 29;642:1-10
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G
Cell reports 2023 Feb 28;42(2):112091
Cell reports 2023 Feb 28;42(2):112091
Perilipin 2 Protects against Lipotoxicity-Induced Islet Fibrosis by Inducing Islet Stellate Cell Activation Phenotype Changes.
Zhou Y, Wang Y, Ni C, Wang H, Zhou J, Wan B, Li H, Li F, Huang R, Xu W, Shan T, Cai T, Kong X, Liu B, Liu X, Sun Z, Ma J
BioMed research international 2022;2022:4581405
BioMed research international 2022;2022:4581405
Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies.
Buser DP, Bader G, Spiess M
Life science alliance 2022 Mar;5(7)
Life science alliance 2022 Mar;5(7)
Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.
Bao X, Ma X, Huang R, Chen J, Xin H, Zhou M, Li L, Tong S, Zhang Q, Shui G, Deng F, Yu L, Li MD, Zhang Z
Journal of molecular cell biology 2022 Dec 26;14(8)
Journal of molecular cell biology 2022 Dec 26;14(8)
ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3.
Zhou L, Song Z, Hu J, Liu L, Hou Y, Zhang X, Yang X, Chen K
Theranostics 2021;11(2):841-860
Theranostics 2021;11(2):841-860
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323
Nature communications 2021 Sep 7;12(1):5323
The autophagy protein ATG9A enables lipid mobilization from lipid droplets.
Mailler E, Guardia CM, Bai X, Jarnik M, Williamson CD, Li Y, Maio N, Golden A, Bonifacino JS
Nature communications 2021 Nov 19;12(1):6750
Nature communications 2021 Nov 19;12(1):6750
Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.
Wang HC, Liu KY, Wang LT, Hsu SH, Wang SC, Huang SK
Human cell 2021 May;34(3):785-799
Human cell 2021 May;34(3):785-799
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis.
Ren M, Xu H, Xia H, Tang Q, Bi F
Cell death discovery 2021 May 29;7(1):125
Cell death discovery 2021 May 29;7(1):125
Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice.
Griffin JD, Bejarano E, Wang XD, Greenberg AS
Cells 2021 Apr 25;10(5)
Cells 2021 Apr 25;10(5)
Feedback activation of GATA1/miR-885-5p/PLIN3 pathway decreases sunitinib sensitivity in clear cell renal cell carcinoma.
Yao D, Xia S, Jin C, Zhao W, Lan W, Liu Z, Xiu Y
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2195-2206
KRAS Controls Pancreatic Cancer Cell Lipid Metabolism and Invasive Potential through the Lipase HSL.
Rozeveld CN, Johnson KM, Zhang L, Razidlo GL
Cancer research 2020 Nov 15;80(22):4932-4945
Cancer research 2020 Nov 15;80(22):4932-4945
O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.
Yang Y, Fu M, Li MD, Zhang K, Zhang B, Wang S, Liu Y, Ni W, Ong Q, Mi J, Yang X
Nature communications 2020 Jan 10;11(1):181
Nature communications 2020 Jan 10;11(1):181
HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation.
van Dierendonck XAMH, de la Rosa Rodriguez MA, Georgiadi A, Mattijssen F, Dijk W, van Weeghel M, Singh R, Borst JW, Stienstra R, Kersten S
Cell reports 2020 Feb 11;30(6):1811-1822.e6
Cell reports 2020 Feb 11;30(6):1811-1822.e6
Multiplex fatty acid imaging inside cells by Raman microscopy.
Uematsu M, Kita Y, Shimizu T, Shindou H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10357-10372
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10357-10372
Targeting PLIN2/PLIN5-PPARγ: Sulforaphane Disturbs the Maturation of Lipid Droplets.
Tian S, Lei P, Teng C, Sun Y, Song X, Li B, Shan Y
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Molecular nutrition & food research 2019 Oct;63(20):e1900183
Delayed recruiting of TPD52 to lipid droplets - evidence for a "second wave" of lipid droplet-associated proteins that respond to altered lipid storage induced by Brefeldin A treatment.
Chen Y, Frost S, Khushi M, Cantrill LC, Yu H, Arthur JW, Bright RK, Groblewski GE, Byrne JA
Scientific reports 2019 Jul 5;9(1):9790
Scientific reports 2019 Jul 5;9(1):9790
Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact.
Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E
Developmental cell 2019 Aug 19;50(4):478-493.e9
Developmental cell 2019 Aug 19;50(4):478-493.e9
Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3.
Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M
Journal of lipid research 2018 May;59(5):805-819
Journal of lipid research 2018 May;59(5):805-819
Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240.
Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, Hirai H, Kurauchi Y, Hisatsune A, Katsuki H
Neurobiology of disease 2018 Dec;120:34-50
Neurobiology of disease 2018 Dec;120:34-50
AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.
Luo H, Jiang M, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY, Lin SC
Cell metabolism 2018 Apr 3;27(4):843-853.e6
Cell metabolism 2018 Apr 3;27(4):843-853.e6
The lipid droplet-associated protein perilipin 3 facilitates hepatitis C virus-driven hepatic steatosis.
Ferguson D, Zhang J, Davis MA, Helsley RN, Vedin LL, Lee RG, Crooke RM, Graham MJ, Allende DS, Parini P, Brown JM
Journal of lipid research 2017 Feb;58(2):420-432
Journal of lipid research 2017 Feb;58(2):420-432
COPI-TRAPPII activates Rab18 and regulates its lipid droplet association.
Li C, Luo X, Zhao S, Siu GK, Liang Y, Chan HC, Satoh A, Yu SS
The EMBO journal 2017 Feb 15;36(4):441-457
The EMBO journal 2017 Feb 15;36(4):441-457
CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis.
Langhi C, Baldán Á
Hepatology (Baltimore, Md.) 2015 Apr;61(4):1227-38
Hepatology (Baltimore, Md.) 2015 Apr;61(4):1227-38
HCV core residues critical for infectivity are also involved in core-NS5A complex formation.
Gawlik K, Baugh J, Chatterji U, Lim PJ, Bobardt MD, Gallay PA
PloS one 2014;9(2):e88866
PloS one 2014;9(2):e88866
Perilipin-5 is regulated by statins and controls triglyceride contents in the hepatocyte.
Langhi C, Marquart TJ, Allen RM, Baldán A
Journal of hepatology 2014 Aug;61(2):358-65
Journal of hepatology 2014 Aug;61(2):358-65
IRG and GBP host resistance factors target aberrant, "non-self" vacuoles characterized by the missing of "self" IRGM proteins.
Haldar AK, Saka HA, Piro AS, Dunn JD, Henry SC, Taylor GA, Frickel EM, Valdivia RH, Coers J
PLoS pathogens 2013;9(6):e1003414
PLoS pathogens 2013;9(6):e1003414
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.
Eastman SW, Yassaee M, Bieniasz PD
The Journal of cell biology 2009 Mar 23;184(6):881-94
The Journal of cell biology 2009 Mar 23;184(6):881-94
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10694-1-AP(M6PRBP1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-M6PRBP1 (IP:10694-1-AP, 3ug; Detection:10694-1-AP 1:1000) with HeLa cells lysate 1000ug.
- Sample type
- cell line