CABT-B10072

antibody from Creative Diagnostics

Targeting: DCLK2 DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B10072

Provider

Creative Diagnostics

Product name

Mouse anti-Human DCLK2 monoclonal antibody, clone 3B6

Antibody type

Monoclonal

Description

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3B6

Vial size

100 _g

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.