Antibody data
- Antibody Data
- Antigen structure
- References [81]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
Submit
Validation data
Reference
Comment
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- Product number
- 10624-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10624-2-AP, RRID:AB_2100801
- Product name
- FASN antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FASN antibody (Cat. #10624-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Functionalized Gadofullerene Ameliorates Impaired Glycolipid Metabolism in Type 2 Diabetic Mice.
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice.
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes.
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Li S, Yan D, Huang C, Yang F, Cao Y
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
The Mutual Inhibition of FoxO1 and SREBP-1c Regulated the Progression of Hepatoblastoma by Regulating Fatty Acid Metabolism.
Hu Y, Zai H, Jiang W, Ou Z, Yao Y, Zhu Q
Mediators of inflammation 2021;2021:5754592
Mediators of inflammation 2021;2021:5754592
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.
Liu W, Wang C, Wang S, Zeng K, Wei S, Sun N, Sun G, Wang M, Zou R, Liu W, Lin L, Song H, Jin Z, Zhao Y
International journal of biological sciences 2021;17(1):188-203
International journal of biological sciences 2021;17(1):188-203
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.
Zhu T, Wang Z, Zou T, Xu L, Zhang S, Chen Y, Chen C, Zhang W, Wang S, Ding Q, Xu G
Frontiers in pharmacology 2021;12:769647
Frontiers in pharmacology 2021;12:769647
Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation.
Shao Y, Wang X, Zhou Y, Jiang Y, Wu R, Lu C
Toxicology 2021 Sep;461:152923
Toxicology 2021 Sep;461:152923
Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding.
Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F, Guo L, Chen M, Liu K, Wu B
Nature communications 2021 Sep 7;12(1):5323
Nature communications 2021 Sep 7;12(1):5323
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
Functionalized Gadofullerene Ameliorates Impaired Glycolipid Metabolism in Type 2 Diabetic Mice.
Wu J, Chen Y, Li X, Ran L, Liu X, Wang X, Zhen M, Shao S, Zeng L, Wang C, Liang B, Zhao J, Wu Y
Journal of genetics and genomics = Yi chuan xue bao 2021 Oct 20;
Journal of genetics and genomics = Yi chuan xue bao 2021 Oct 20;
Comprehensive multi-omics approaches reveal the hepatotoxic mechanism of perfluorohexanoic acid (PFHxA) in mice.
Jiang L, Hong Y, Xie G, Zhang J, Zhang H, Cai Z
The Science of the total environment 2021 Oct 10;790:148160
The Science of the total environment 2021 Oct 10;790:148160
Exercise improves lipid metabolism disorders induced by high-fat diet in a SESN2/JNK-independent manner.
Wang T, Hu W, Niu Y, Liu S, Fu L
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2021 Nov;46(11):1322-1330
Changes of lipid profiles in human umbilical vein endothelial cells exposed to zirconia nanoparticles with or without the presence of free fatty acids.
Cheng X, Guo H, Xian Y, Xie X
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Journal of applied toxicology : JAT 2021 May;41(5):765-774
Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.
Yang Y, Han A, Wang X, Yin X, Cui M, Lin Z
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Journal of cellular and molecular medicine 2021 May;25(10):4846-4859
Apple polyphenol extract alleviates lipid accumulation in free-fatty-acid-exposed HepG2 cells via activating autophagy mediated by SIRT1/AMPK signaling.
Li D, Cui Y, Wang X, Liu F, Li X
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Phytotherapy research : PTR 2021 Mar;35(3):1416-1431
Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission.
You YN, Xing QQ, Zhao X, Ji JJ, Yan H, Zhou T, Dong YM, Ren LS, Hou ST, Ding YY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111403
BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis.
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, Liu H, Liu Y, Pan D, Tang Y, Tang QQ
Redox biology 2021 Jul;43:101979
Redox biology 2021 Jul;43:101979
Dietary L-arginine supplementation of tilapia (Oreochromis niloticus) alters the microbial population and activates intestinal fatty acid oxidation.
Li S, Wang C, Wu Z
Amino acids 2021 Jul 2;
Amino acids 2021 Jul 2;
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482
The Journal of biological chemistry 2021 Jan-Jun;296:100482
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells.
Luo Y, Wang X, Cao Y
Chemico-biological interactions 2021 Jan 5;333:109325
Chemico-biological interactions 2021 Jan 5;333:109325
Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.
Tao L, Guo X, Xu M, Wang Y, Xie W, Chen H, Ma M, Li X
Pharmacology research & perspectives 2021 Feb;9(1):e00700
Pharmacology research & perspectives 2021 Feb;9(1):e00700
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H
Science translational medicine 2021 Dec 15;13(624):eabg8116
Science translational medicine 2021 Dec 15;13(624):eabg8116
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Huang D, Xu B, Liu L, Wu L, Zhu Y, Ghanbarpour A, Wang Y, Chen FJ, Lyu J, Hu Y, Kang Y, Zhou W, Wang X, Ding W, Li X, Jiang Z, Chen J, Zhang X, Zhou H, Li JZ, Guo C, Zheng W, Zhang X, Li P, Melia T, Reinisch K, Chen XW
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Cell metabolism 2021 Aug 3;33(8):1655-1670.e8
Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice.
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, Chen Z, Wang Y, Zou Q, Wang L
European journal of nutrition 2021 Apr;60(3):1655-1668
European journal of nutrition 2021 Apr;60(3):1655-1668
Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway.
Li J, Ding X, Jian T, Lü H, Zhao L, Li J, Liu Y, Ren B, Chen J
PeerJ 2020;8:e10413
PeerJ 2020;8:e10413
Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.
Li L, Zheng W, Wang C, Qi J, Li H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7826874
LncRNA DNAJC3-AS1 Regulates Fatty Acid Synthase via the EGFR Pathway to Promote the Progression of Colorectal Cancer.
Tang Y, Tang R, Tang M, Huang P, Liao Z, Zhou J, Zhou L, Su M, Chen P, Jiang J, Hu Y, Zhou Y, Liao Q, Zeng Z, Xiong W, Chen J, Nie S
Frontiers in oncology 2020;10:604534
Frontiers in oncology 2020;10:604534
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, Chen J, Gong Z, Liu Z, Xiao W
Food & function 2020 Sep 23;11(9):8369-8379
Food & function 2020 Sep 23;11(9):8369-8379
Disruption of Plin5 degradation by CMA causes lipid homeostasis imbalance in NAFLD.
Ma SY, Sun KS, Zhang M, Zhou X, Zheng XH, Tian SY, Liu YS, Chen L, Gao X, Ye J, Zhou XM, Wang JB, Han Y
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Liver international : official journal of the International Association for the Study of the Liver 2020 Oct;40(10):2427-2438
Fatty acid synthase contributes to epithelial-mesenchymal transition and invasion of salivary adenoid cystic carcinoma through PRRX1/Wnt/β-catenin pathway.
Zhang WL, Wang SS, Jiang YP, Liu Y, Yu XH, Wu JB, Wang K, Pang X, Liao P, Liang XH, Tang YL
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Journal of cellular and molecular medicine 2020 Oct;24(19):11465-11476
Effect and mechanism of ginsenoside Rg1-regulating hepatic steatosis in HepG2 cells induced by free fatty acid.
Gao Y, Zhang S, Li J, Zhao J, Xiao Q, Zhu Y, Zhang J, Huang W
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Bioscience, biotechnology, and biochemistry 2020 Nov;84(11):2228-2240
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Zeng Y, Hua YQ, Wang W, Zhang H, Xu XL
Biochemical pharmacology 2020 May;175:113927
Biochemical pharmacology 2020 May;175:113927
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
The lncRNA Gm15622 stimulates SREBP-1c expression and hepatic lipid accumulation by sponging the miR-742-3p in mice.
Ma M, Duan R, Shen L, Liu M, Ji Y, Zhou H, Li C, Liang T, Li X, Guo L
Journal of lipid research 2020 Jul;61(7):1052-1064
Journal of lipid research 2020 Jul;61(7):1052-1064
Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor.
Wang X, Du G, Wu Y, Zhang Y, Guo F, Liu W, Wu R
International journal of oncology 2020 Feb;56(2):568-580
International journal of oncology 2020 Feb;56(2):568-580
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, Song X, Zhao T, Ye L
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Environmental science and pollution research international 2020 Feb;27(4):3837-3848
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life sciences 2020 Feb 1;242:117221
Life sciences 2020 Feb 1;242:117221
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539
Journal of thermal biology 2020 Apr;89:102539
Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.
Wu K, Yin X, Jin Y, Liu F, Gao J
Cancer cell international 2019;19:51
Cancer cell international 2019;19:51
Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma.
Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, Zuo Q, Yu C, Wang H, Lv Y, Gu D, Jin G, Yao M, Qin W, Jin H
Journal of Cancer 2019;10(4):918-926
Journal of Cancer 2019;10(4):918-926
A Novel Regulatory Circuit "C/EBPα/miR-20a-5p/TOB2" Regulates Adipogenesis and Lipogenesis.
Zhou J, Yang J, Wang X, Li M, Li F, Zhu E, Li X, Li X, Wang B
Frontiers in endocrinology 2019;10:894
Frontiers in endocrinology 2019;10:894
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway.
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10089-10103
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection.
Chen J, Zhou Y, Zhuang Y, Qin T, Guo M, Jiang J, Niu J, Li JZ, Chen X, Wang Q
Metabolism: clinical and experimental 2019 Nov;100:153954
Metabolism: clinical and experimental 2019 Nov;100:153954
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Meng Z, Liu Q, Sun F, Qiao L
Lipids in health and disease 2019 Nov 4;18(1):191
Lipids in health and disease 2019 Nov 4;18(1):191
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, Zhang X, Zhou L, Ye L
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Ecotoxicology and environmental safety 2019 Nov 30;184:109611
Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII.
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, Tan N
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Biochemical and biophysical research communications 2019 May 14;512(4):819-824
Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats.
Zhang YZ, Zhang ZM, Zhou LT, Zhu J, Zhang XH, Qi W, Ding S, Xu Q, Han X, Zhao YM, Song XY, Zhao TY, Ye L
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Biomedical and environmental sciences : BES 2019 Jun;32(6):406-418
Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells.
Bai J, He Z, Li Y, Jiang X, Yu H, Tan Q
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Environmental toxicology and pharmacology 2019 Jul;69:104-111
Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver.
Luo M, Huang S, Zhang J, Zhang L, Mehmood K, Jiang J, Zhang N, Zhou D
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Environmental science and pollution research international 2019 Jul;26(21):21828-21834
Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota.
Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
World journal of gastroenterology 2019 Jul 21;25(27):3590-3606
Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells.
Yang H, Li J, Yang C, Liu H, Cao Y
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Toxicology and applied pharmacology 2019 Jul 1;374:11-19
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism.
Wu JS, Zheng M, Zhang M, Pang X, Li L, Wang SS, Yang X, Wu JB, Tang YJ, Tang YL, Liang XH
Frontiers in microbiology 2018;9:2081
Frontiers in microbiology 2018;9:2081
Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes.
Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2881-2889
RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome.
Trotman JB, Agana BA, Giltmier AJ, Wysocki VH, Schoenberg DR
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
The Journal of biological chemistry 2018 Oct 26;293(43):16596-16607
Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival.
Li D, Tian G, Wang J, Zhao LY, Co O, Underill ZC, Mymryk JS, Claessens F, Dehm SM, Daaka Y, Liao D
The Prostate 2018 Nov;78(15):1140-1156
The Prostate 2018 Nov;78(15):1140-1156
Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues.
Wallace M, Green CR, Roberts LS, Lee YM, McCarville JL, Sanchez-Gurmaches J, Meurs N, Gengatharan JM, Hover JD, Phillips SA, Ciaraldi TP, Guertin DA, Cabrales P, Ayres JS, Nomura DK, Loomba R, Metallo CM
Nature chemical biology 2018 Nov;14(11):1021-1031
Nature chemical biology 2018 Nov;14(11):1021-1031
Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice.
Chen S, Li X, Liu L, Liu C, Han X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Mar;32(3):1139-1153
Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells.
Qiao X, Li Y, Mai J, Ji X, Li Q
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Molecules (Basel, Switzerland) 2018 Jul 6;23(7)
Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury.
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z
Scientific reports 2018 Jan 11;8(1):408
Scientific reports 2018 Jan 11;8(1):408
Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice.
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, Sun P, Ma X, Peng J, Liu K
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Journal of gastroenterology and hepatology 2018 Feb;33(2):533-542
Lack of β, β-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.
Wu L, Guo X, Hartson SD, Davis MA, He H, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, von Lintig J, Lin D
Molecular nutrition & food research 2017 May;61(5)
Molecular nutrition & food research 2017 May;61(5)
Embelin attenuates adipogenesis and lipogenesis through activating canonical Wnt signaling and inhibits high-fat diet-induced obesity.
Gao Y, Li J, Xu X, Wang S, Yang Y, Zhou J, Zhang L, Zheng F, Li X, Wang B
International journal of obesity (2005) 2017 May;41(5):729-738
International journal of obesity (2005) 2017 May;41(5):729-738
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes.
Tang LL, Wang JD, Xu TT, Zhao Z, Zheng JJ, Ge RS, Zhu DY
Toxicology 2017 May 1;382:108-116
Toxicology 2017 May 1;382:108-116
Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Meng Q, Duan XP, Wang CY, Liu ZH, Sun PY, Huo XK, Sun HJ, Peng JY, Liu KX
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Acta pharmacologica Sinica 2017 Jan;38(1):69-79
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN.
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, Fan S
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Biochemical and biophysical research communications 2017 Jan 22;482(4):1246-1251
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner.
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, Hou L, Liang R
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Environmental toxicology and pharmacology 2017 Dec;56:15-20
Impact of FHIT loss on the translation of cancer-associated mRNAs.
Kiss DL, Baez W, Huebner K, Bundschuh R, Schoenberg DR
Molecular cancer 2017 Dec 28;16(1):179
Molecular cancer 2017 Dec 28;16(1):179
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
Iwakoshi-Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, Sasaki T, Okamoto S, Bentley GE, Kriegsfeld LJ, Minokoshi Y, Ukena K
eLife 2017 Aug 11;6
eLife 2017 Aug 11;6
The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes.
Zhang Y, Yu H, Gao P, Chen J, Yu C, Zong C, Lu S, Li X, Ma X, Liu Y, Wang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2135-2148
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(6):2135-2148
Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Yang W, She L, Yu K, Yan S, Zhang X, Tian X, Ma S, Zhang X
Molecular medicine reports 2016 Oct;14(4):3277-84
Molecular medicine reports 2016 Oct;14(4):3277-84
Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway.
Wang H, Xi Q, Wu G
Cancer medicine 2016 Jul;5(7):1599-606
Cancer medicine 2016 Jul;5(7):1599-606
miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer.
Xin M, Qiao Z, Li J, Liu J, Song S, Zhao X, Miao P, Tang T, Wang L, Liu W, Yang X, Dai K, Huang G
Oncotarget 2016 Jul 12;7(28):44252-44265
Oncotarget 2016 Jul 12;7(28):44252-44265
Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms.
Cai D, Wang J, Jia Y, Liu H, Yuan M, Dong H, Zhao R
Biochimica et biophysica acta 2016 Jan;1861(1):41-50
Biochimica et biophysica acta 2016 Jan;1861(1):41-50
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes.
Chen J, Ren J, Jing Q, Lu S, Zhang Y, Liu Y, Yu C, Gao P, Zong C, Li X, Wang X
Journal of cellular physiology 2015 Sep;230(9):2233-9
Journal of cellular physiology 2015 Sep;230(9):2233-9
Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway.
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, Sun B, Ye L, Zhang X
Cancer research 2015 Mar 1;75(5):846-57
Cancer research 2015 Mar 1;75(5):846-57
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10624-2-AP(FASN antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using FASN antibody 10624-2-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-FASN (IP:10624-2-AP, 4ug; Detection:10624-2-AP 1:500) with mouse liver tissue lysate 4000ug.
- Sample type
- tissue