CABT-BL4380

antibody from Creative Diagnostics

Targeting: CLDN15

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-BL4380

Provider

Creative Diagnostics

Product name

Anti-CLDN15 (C-terminal) polyclonal antibody

Antibody type

Polyclonal

Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein increases permeability for sodium ions in anion-selective epithelial cell sheets. The gene deficiency leads to megaintestine and decreases in intestinal epithelial paracellular ion permeability. This gene is a direct target for hepatocyte-nuclear-factor-4alpha, a mediator of ion epithelial transport, and is down-modulated in inflammatory bowel disease. [provided by RefSeq, Aug 2010]

Reactivity

Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

Lyophilized product, 5 years at 2 - 8°C