606602

antibody from BioLegend
Targeting: NR5A2 B1F2, FTF, FTZ-F1, FTZ-F1beta, hB1F, hB1F-2, LRH-1, LRH1
Provider product page for 606602

Antibody data

Product number
606602 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#606602, RRID:AB_2154056
Product name
Purified anti-CPF
Antibody type
Polyclonal
Antigen
Peptide corresponding to amino acids 1-67 of human CPF, member 2, variant 2
Description
CPF, also known as nuclear receptor subfamily 5 group A member 2, orphan nuclear receptor NR5A2, HB1F, fetoprotein transcription factor, FTF, CYP7A promoter binding factor, and LRH1 is a 54 kD nuclear receptor protein. CPF is a member of the FTZ-F1 sub-family and is highly expressed in the pancreas and to a lesser extent in the liver. CPF contains a DNA binding domain, a hormone ligand-binding domain, and two zinc finger domains and binds to DNA as a monomer. CPF is known to regulate transcription of the liver enzyme cholesterol 7-alpha-hydrolase that converts cholesterol to bile acids and to activate the hepatitis B virus enhancer II to contribute to the liver-specific expression of this virus. CPF interacts with multiprotein bridging actor 1 and the orphan nuclear receptor SHP and has been suggested to regulate pancreas-specific gene expression and play a role in embryonic development. There are at least 3 alternatively spliced isoforms of CPF; isoforms 1 and 2 are present in fetal and adult liver and in liver cancer cells such as HepG2. The Poly6066 recognizes human CPF (amino acids 1-67) and has been shown to be useful for Western blotting.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
200 µl
Storage
Upon receipt, store frozen at -20° C.
NR5A2 protein structure - 606602 shown in red.