orb67250

antibody from Biorbyt

Targeting: SYVN1 DER3, HRD1

Western blot (Data presented on provider website)

Antibody Data

Product number

orb67250

Provider

Biorbyt

Product name

SYVN1 antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Vial size

100 ul

Storage

-20°C