Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11776-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11776-1-AP, RRID:AB_2298317
- Product name
- NAMPT/PBEF antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NAMPT/PBEF antibody (Cat. #11776-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, zebrafish and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass.
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice.
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD+ homeostasis.
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X
Drug design, development and therapy 2021;15:51-60
Drug design, development and therapy 2021;15:51-60
Impaired Nicotinamide Adenine Dinucleotide Biosynthesis in the Kidney of Chronic Kidney Disease.
Liu X, Luo D, Huang S, Liu S, Zhang B, Wang F, Lu J, Chen J, Li S
Frontiers in physiology 2021;12:723690
Frontiers in physiology 2021;12:723690
Nicotinamide improves NAD+ levels to protect against acetaminophen-induced acute liver injury in mice.
Xu J, Zhang L, Jiang R, Hu K, Hu D, Liao C, Jiang S, Yang Y, Huang J, Tang L, Li L
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Human & experimental toxicology 2021 Nov;40(11):1938-1946
Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Li Y, Li J, Zhao C, Yang L, Qi X, Wang X, Zhou Q, Shi W
Metabolism: clinical and experimental 2021 Jan;114:154402
Metabolism: clinical and experimental 2021 Jan;114:154402
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H
Cell metabolism 2021 Jan 5;33(1):110-127.e5
Cell metabolism 2021 Jan 5;33(1):110-127.e5
CD38 and MGluR1 as possible signaling molecules involved in epileptogenesis: A potential role for NAD+ homeostasis.
Khodaverdian S, Dashtban-Moghadam E, Dabirmanesh B, Mirnajafi-Zadeh J, Taleb M, Khajeh K, Fathollahi Y
Brain research 2021 Aug 15;1765:147509
Brain research 2021 Aug 15;1765:147509
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice.
Zhou Q, Zhu L, Qiu W, Liu Y, Yang F, Chen W, Xu R
International journal of biological sciences 2020;16(2):284-297
International journal of biological sciences 2020;16(2):284-297
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Gibson AE, Yeung C, Issaq SH, Collins VJ, Gouzoulis M, Zhang Y, Ji J, Mendoza A, Heske CM
Oncogenesis 2020 Sep 10;9(9):80
Oncogenesis 2020 Sep 10;9(9):80
NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer.
Li XQ, Lei J, Mao LH, Wang QL, Xu F, Ran T, Zhou ZH, He S
Frontiers in oncology 2019;9:736
Frontiers in oncology 2019;9:736
NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice.
Xiong X, Yu J, Fan R, Zhang C, Xu L, Sun X, Huang Y, Wang Q, Ruan HB, Qian X
PloS one 2019;14(2):e0212523
PloS one 2019;14(2):e0212523
Dietary Antioxidant Trans-Cinnamaldehyde Reduced Visfatin-Induced Breast Cancer Progression: In Vivo and In Vitro Study.
Chiang YF, Chen HY, Huang KC, Lin PH, Hsia SM
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Antioxidants (Basel, Switzerland) 2019 Dec 6;8(12)
Corneal Denervation Causes Epithelial Apoptosis Through Inhibiting NAD+ Biosynthesis.
Li Y, Ma X, Li J, Yang L, Zhao X, Qi X, Zhang X, Zhou Q, Shi W
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Investigative ophthalmology & visual science 2019 Aug 1;60(10):3538-3546
Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice.
Sun Y, Tian Z, Liu N, Zhang L, Gao Z, Sun X, Yu M, Wu J, Yang F, Zhao Y, Ren H, Chen H, Zhao D, Wang Y, Dong S, Xu C, Lu F, Zhang W
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
Journal of molecular medicine (Berlin, Germany) 2018 Apr;96(3-4):281-299
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy.
Yue Z, Ma Y, You J, Li Z, Ding Y, He P, Lu X, Jiang J, Chen S, Liu P
Experimental cell research 2016 Oct 1;347(2):261-73
Experimental cell research 2016 Oct 1;347(2):261-73
Effect of curcumin on visfatin and zinc-α2-glycoprotein in a rat model of non-alcoholic fatty liver disease.
Li C, Li J, Chen Y, Zhong X, Kang M
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Acta cirurgica brasileira 2016 Nov;31(11):706-713
Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing.
Zhou CC, Yang X, Hua X, Liu J, Fan MB, Li GQ, Song J, Xu TY, Li ZY, Guan YF, Wang P, Miao CY
British journal of pharmacology 2016 Aug;173(15):2352-68
British journal of pharmacology 2016 Aug;173(15):2352-68
Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.
Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
Cancer cell 2014 Dec 8;26(6):826-839
Cancer cell 2014 Dec 8;26(6):826-839
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 11776-1-AP(NAMPT antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NAMPT (IP:11776-1-AP, 3ug; Detection:11776-1-AP 1:1000) with mouse heart tissue lysate 4000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Visfatin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Visfatin. This antibody recognizes human,mouse,rat, zebrafish antigen. The Visfatin antibody has been validated for the following applications: ELISA, IHC, WB, IP analysis.