TKTL1

The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Description

Transketolase like 1

Tissue specificity

Tissue enriched (testis)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (154295795 - 154330350)

Ensembl ID

ENSG00000007350  (ver. 103.38)

Orthologs

Mouse Tktl1: ENSMUSG00000031397

UniProt

P51854

neXtProt

NX_P51854

Human splice variants
Mouse splice variants

Protein structure