NBP1-87852

antibody from Novus Biologicals

Targeting: PTGES MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12

Western blot (Supportive data in Antibodypedia)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

NBP1-87852

Provider

Novus Biologicals

Proper citation

Novus Cat#NBP1-87852, RRID:AB_11007086

Product name

Rabbit Polyclonal Prostaglandin E Synthase Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Specificity of human Prostaglandin E Synthase antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

References

Submitted references

Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis.

Toda K, Ueyama M, Tanaka S, Tsukayama I, Mega T, Konoike Y, Tamenobu A, Bastian F, Akai I, Ito H, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T
Bioscience, biotechnology, and biochemistry 2020 Apr;84(4):757-763

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The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma.

Kim SH, Roszik J, Cho SN, Ogata D, Milton DR, Peng W, Menter DG, Ekmekcioglu S, Grimm EA
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Mar 1;25(5):1650-1663

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Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression.

Kim SH, Hashimoto Y, Cho SN, Roszik J, Milton DR, Dal F, Kim SF, Menter DG, Yang P, Ekmekcioglu S, Grimm EA
Pigment cell & melanoma research 2016 May;29(3):297-308

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Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury.

Yao L, Chen W, Han C, Wu T
American journal of physiology. Gastrointestinal and liver physiology 2016 Jun 1;310(11):G1071-80

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Active smoking increases microsomal PGE2-synthase-1/PGE-receptor-4 axis in human abdominal aortic aneurysms.

Dilmé JF, Solà-Villà D, Bellmunt S, Romero JM, Escudero JR, Camacho M, Vila L
Mediators of inflammation 2014;2014:316150

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Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.

Camacho M, Dilmé J, Solà-Villà D, Rodríguez C, Bellmunt S, Siguero L, Alcolea S, Romero JM, Escudero JR, Martínez-González J, Vila L
Journal of lipid research 2013 Dec;54(12):3506-15

Western blot

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Western Blot: Prostaglandin E Synthase Antibody [NBP1-87852] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Western Blot: Prostaglandin E Synthase Antibody [NBP1-87852] - Analysis in human cell lines A-549 and U-251MG. Corresponding RNA-seq data are presented for the same cell lines. Loading control: Anti-GAPDH.

Immunohistochemistry

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human endometrium shows low expression as expected.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human seminal vesicle shows high expression.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Analysis in human seminal vesicle and pancreas tissues. Corresponding Prostaglandin E Synthase RNA-seq data are presented for the same tissues.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human placenta shows strong cytoplasmic positivity in decidual cells.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human seminal vesicle shows strong membranous and cytoplasmic positivity in glandular cells.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human testis shows weak to moderate membranous and cytoplasmic positivity in cells in seminiferous ducts.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: Prostaglandin E Synthase Antibody [NBP1-87852] - Staining of human urinary bladder shows moderate cytoplasmic positivity in urothelial cells.