MMP7

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

Description

Matrix metallopeptidase 7

Tissue specificity

Tissue enhanced (gallbladder, salivary gland, urinary bladder)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Secreted to extracellular matrix

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (102520508 - 102530750)

Ensembl ID

ENSG00000137673  (ver. 103.38)

Orthologs

Mouse Mmp7: ENSMUSG00000018623

UniProt

P09237

neXtProt

NX_P09237

Human splice variants
Mouse splice variants

Protein structure