Tissue expression
Cell line expression
Protein structure
RNF7
Ring finger protein 7CKBBP1, ROC2, SAG
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | 11905-1-AP | 3 references | Polyclonal |
WB
EL
ICC
IP |
|
Invitrogen Antibodies | 11905-1-AP | Polyclonal |
WB
ICC
IP
OA |
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Novus Biologicals | NBP1-46159 | 1 references | Polyclonal |
WB
EL
IHC
|
|
LSBio | LS-C392690 | Polyclonal |
WB
EL
IHC
|
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NovoPro Bioscience Inc. | 114763 | Polyclonal |
WB
EL
ICC
IP |
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider