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- References [13]
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- Product number
- NBP1-00861 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-00861, RRID:AB_1503315
- Product name
- Rabbit Polyclonal SUCNR1/GPR91 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. GPR91 (A135) detects endogenous levels of GPR91 protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Cinnamaldehyde suppresses NLRP3 derived IL-1β via activating succinate/HIF-1 in rheumatoid arthritis rats.
Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.
Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling.
A CD4(+) T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis.
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells.
Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy.
ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes.
Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Liu P, Wang J, Wen W, Pan T, Chen H, Fu Y, Wang F, Huang JH, Xu S
International immunopharmacology 2020 Jul;84:106570
International immunopharmacology 2020 Jul;84:106570
Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor.
Wu JY, Huang TW, Hsieh YT, Wang YF, Yen CC, Lee GL, Yeh CC, Peng YJ, Kuo YY, Wen HT, Lin HC, Hsiao CW, Wu KK, Kung HJ, Hsu YJ, Kuo CC
Molecular cell 2020 Jan 16;77(2):213-227.e5
Molecular cell 2020 Jan 16;77(2):213-227.e5
Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling.
Wang T, Xu YQ, Yuan YX, Xu PW, Zhang C, Li F, Wang LN, Yin C, Zhang L, Cai XC, Zhu CJ, Xu JR, Liang BQ, Schaul S, Xie PP, Yue D, Liao ZR, Yu LL, Luo L, Zhou G, Yang JP, He ZH, Du M, Zhou YP, Deng BC, Wang SB, Gao P, Zhu XT, Xi QY, Zhang YL, Shu G, Jiang QY
EMBO reports 2019 Sep;20(9):e47892
EMBO reports 2019 Sep;20(9):e47892
A CD4(+) T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.
Caielli S, Veiga DT, Balasubramanian P, Athale S, Domic B, Murat E, Banchereau R, Xu Z, Chandra M, Chung CH, Walters L, Baisch J, Wright T, Punaro M, Nassi L, Stewart K, Fuller J, Ucar D, Ueno H, Zhou J, Banchereau J, Pascual V
Nature medicine 2019 Jan;25(1):75-81
Nature medicine 2019 Jan;25(1):75-81
Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.
Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S
Cell stem cell 2018 Mar 1;22(3):355-368.e13
Cell stem cell 2018 Mar 1;22(3):355-368.e13
Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.
Nguyen G, Park SY, Le CT, Park WS, Choi DH, Cho EH
Biochemical and biophysical research communications 2018 Jan 22;495(4):2649-2656
Biochemical and biophysical research communications 2018 Jan 22;495(4):2649-2656
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis.
Guo Y, Xie C, Li X, Yang J, Yu T, Zhang R, Zhang T, Saxena D, Snyder M, Wu Y, Li X
Nature communications 2017 May 31;8:15621
Nature communications 2017 May 31;8:15621
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.
Mu X, Zhao T, Xu C, Shi W, Geng B, Shen J, Zhang C, Pan J, Yang J, Hu S, Lv Y, Wen H, You Q
Oncotarget 2017 Feb 21;8(8):13174-13185
Oncotarget 2017 Feb 21;8(8):13174-13185
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
Li T, Hu J, Gao F, Du X, Chen Y, Wu Q
Scientific reports 2017 Apr 4;7:45807
Scientific reports 2017 Apr 4;7:45807
The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells.
Hu J, Li T, Du S, Chen Y, Wang S, Xiong F, Wu Q
International journal of molecular medicine 2015 Jul;36(1):130-8
International journal of molecular medicine 2015 Jul;36(1):130-8
Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy.
Yang L, Yu D, Fan HH, Feng Y, Hu L, Zhang WY, Zhou K, Mo XM
International journal of clinical and experimental pathology 2014;7(9):5415-28
International journal of clinical and experimental pathology 2014;7(9):5415-28
ERK1/2/COX-2/PGE2 signaling pathway mediates GPR91-dependent VEGF release in streptozotocin-induced diabetes.
Li T, Hu J, Du S, Chen Y, Wang S, Wu Q
Molecular vision 2014;20:1109-21
Molecular vision 2014;20:1109-21
Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Hu J, Wu Q, Li T, Chen Y, Wang S
Experimental eye research 2013 Apr;109:31-9
Experimental eye research 2013 Apr;109:31-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SUCNR1/GPR91 Antibody [NBP1-00861] - Analysis of human kidney tissue (A), mouse kidney tissue (B), rat kidney tissue (C), and hek293 cells (D) using GPR91 antibody at 2ug/ml.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SUCNR1/GPR91 Antibody [NBP1-00861] - Lane1:Hela whole cell lysate. Lane2:Mouse kidney tissue lysate. Lane3:Rat kidney tissue lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SUCNR1/GPR91 Antibody [NBP1-00861] - Analysis of GPR91 (A135) antibody in extracts from HUVEC/MCF-7 cells.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SUCNR1/GPR91 Antibody [NBP1-00861] - Staining of GPR91 in mouse Vas Deferens where strong membrane staining is observed.
