PTPN4

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

Description

Protein tyrosine phosphatase non-receptor type 4

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoplasm, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

2 (119759922 - 119984899)

Ensembl ID

ENSG00000088179  (ver. 103.38)

Orthologs

Mouse Ptpn4: ENSMUSG00000026384

UniProt

P29074

neXtProt

NX_P29074

Human splice variants
Mouse splice variants

Protein structure