Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 16206-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16206-1-AP, RRID:AB_10637856
- Product name
- MKS1 antibody
- Antibody type
- Polyclonal
- Description
- MKS1 antibody (Cat. #16206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
The small GTPase RSG1 controls a final step in primary cilia initiation.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Lineage specificity of primary cilia in the mouse embryo.
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.
Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Visualizing renal primary cilia.
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY
The Journal of cell biology 2022 Jan 3;221(1)
The Journal of cell biology 2022 Jan 3;221(1)
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Chen C, Xu Q, Zhang Y, Davies BA, Huang Y, Katzmann DJ, Harris PC, Hu J, Ling K
Science advances 2021 Jun;7(26)
Science advances 2021 Jun;7(26)
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.
Ran J, Liu M, Feng J, Li H, Ma H, Song T, Cao Y, Zhou P, Wu Y, Yang Y, Yang Y, Yu F, Guo H, Zhang L, Xie S, Li D, Gao J, Zhang X, Zhu X, Zhou J
Developmental cell 2020 May 4;53(3):287-299.e5
Developmental cell 2020 May 4;53(3):287-299.e5
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C
The EMBO journal 2018 May 15;37(10)
The EMBO journal 2018 May 15;37(10)
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275
Biophysical journal 2018 Jul 17;115(2):263-275
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K
Journal of cell science 2018 Jan 8;131(1)
Journal of cell science 2018 Jan 8;131(1)
The small GTPase RSG1 controls a final step in primary cilia initiation.
Agbu SO, Liang Y, Liu A, Anderson KV
The Journal of cell biology 2018 Jan 2;217(1):413-427
The Journal of cell biology 2018 Jan 2;217(1):413-427
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
INPP5E regulates phosphoinositide-dependent cilia transition zone function.
Dyson JM, Conduit SE, Feeney SJ, Hakim S, DiTommaso T, Fulcher AJ, Sriratana A, Ramm G, Horan KA, Gurung R, Wicking C, Smyth I, Mitchell CA
The Journal of cell biology 2017 Jan 2;216(1):247-263
The Journal of cell biology 2017 Jan 2;216(1):247-263
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R, UK10K Rare Diseases Group.
Nature communications 2016 May 13;7:11491
Nature communications 2016 May 13;7:11491
Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Burnicka-Turek O, Steimle JD, Huang W, Felker L, Kamp A, Kweon J, Peterson M, Reeves RH, Maslen CL, Gruber PJ, Yang XH, Shendure J, Moskowitz IP
Human molecular genetics 2016 Jul 15;25(14):3011-3028
Human molecular genetics 2016 Jul 15;25(14):3011-3028
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
Slaats GG, Isabella CR, Kroes HY, Dempsey JC, Gremmels H, Monroe GR, Phelps IG, Duran KJ, Adkins J, Kumar SA, Knutzen DM, Knoers NV, Mendelsohn NJ, Neubauer D, Mastroyianni SD, Vogt J, Worgan L, Karp N, Bowdin S, Glass IA, Parisi MA, Otto EA, Johnson CA, Hildebrandt F, van Haaften G, Giles RH, Doherty D
Journal of medical genetics 2016 Jan;53(1):62-72
Journal of medical genetics 2016 Jan;53(1):62-72
Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis.
Xu Q, Zhang Y, Wei Q, Huang Y, Hu J, Ling K
Nature communications 2016 Feb 26;7:10777
Nature communications 2016 Feb 26;7:10777
Superresolution Pattern Recognition Reveals the Architectural Map of the Ciliary Transition Zone.
Yang TT, Su J, Wang WJ, Craige B, Witman GB, Tsou MF, Liao JC
Scientific reports 2015 Sep 14;5:14096
Scientific reports 2015 Sep 14;5:14096
Lineage specificity of primary cilia in the mouse embryo.
Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV
Nature cell biology 2015 Feb;17(2):113-22
Nature cell biology 2015 Feb;17(2):113-22
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Ran J, Yang Y, Li D, Liu M, Zhou J
Scientific reports 2015 Aug 6;5:12917
Scientific reports 2015 Aug 6;5:12917
TMEM231, mutated in orofaciodigital and Meckel syndromes, organizes the ciliary transition zone.
Roberson EC, Dowdle WE, Ozanturk A, Garcia-Gonzalo FR, Li C, Halbritter J, Elkhartoufi N, Porath JD, Cope H, Ashley-Koch A, Gregory S, Thomas S, Sayer JA, Saunier S, Otto EA, Katsanis N, Davis EE, Attié-Bitach T, Hildebrandt F, Leroux MR, Reiter JF
The Journal of cell biology 2015 Apr 13;209(1):129-42
The Journal of cell biology 2015 Apr 13;209(1):129-42
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J
Cell research 2014 Nov;24(11):1342-53
Cell research 2014 Nov;24(11):1342-53
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.
Hall EA, Keighren M, Ford MJ, Davey T, Jarman AP, Smith LB, Jackson IJ, Mill P
PLoS genetics 2013;9(12):e1003928
PLoS genetics 2013;9(12):e1003928
Fused (Stk36) is a ciliary protein required for central pair assembly and motile cilia orientation in the mammalian oviduct.
Nozawa YI, Yao E, Lin C, Yang JH, Wilson CW, Gacayan R, Chuang PT
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Nov;242(11):1307-19
Developmental dynamics : an official publication of the American Association of Anatomists 2013 Nov;242(11):1307-19
Visualizing renal primary cilia.
Deane JA, Verghese E, Martelotto LG, Cain JE, Galtseva A, Rosenblum ND, Watkins DN, Ricardo SD
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis.
Goetz SC, Liem KF Jr, Anderson KV
Cell 2012 Nov 9;151(4):847-858
Cell 2012 Nov 9;151(4):847-858
A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.
Garcia-Gonzalo FR, Corbit KC, Sirerol-Piquer MS, Ramaswami G, Otto EA, Noriega TR, Seol AD, Robinson JF, Bennett CL, Josifova DJ, García-Verdugo JM, Katsanis N, Hildebrandt F, Reiter JF
Nature genetics 2011 Jul 3;43(8):776-84
Nature genetics 2011 Jul 3;43(8):776-84
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 16206-1-AP(BBS13 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-BBS13 (IP:16206-1-AP, 3ug; Detection:16206-1-AP 1:1000) with HEK-293 cells lysate 4500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 16206-1-AP(BBS13 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 16206-1-AP(BBS13 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue