orb1730141

antibody from Biorbyt
Targeting: HEXIM1 CLP-1, EDG1, HIS1, MAQ1
Provider product page for orb1730141
Western blot
ELISA
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
orb1730141 - Provider product page
Provider
Biorbyt
Product name
HEXIM1 Antibody
Antibody type
Polyclonal
Description
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 ul
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
HEXIM1 protein structure - orb1730141 shown in red.