APG01133G

antibody from Leading Biology

Targeting: PTTG1 EAP1, HPTTG, PTTG, securin, TUTR1

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APG01133G

Provider

Leading Biology

Product name

Securin / PTTG1 Antibody (aa148-160)

Antibody type

Polyclonal

Description

Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Reactivity

Human, Mouse, Simian

Host

Goat

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.