BS6636
antibody from Bioworld Technology, Inc
Targeting: IL10RA
CD210, CD210a, CDW210A, HIL-10R, IL10R
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS6636 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL 10RA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL-10RA.
- Description
- The IL-10 receptor, IL-10R, is a member of the class II subgroup of the cytokine receptor family and exhibits structural similarity to the interferon receptor. IL-10R is expressed in B cells and T helper cells, as well as in LPS-induced mouse fibroblasts. Overall, mouse IL-10R and human IL-10R share 60% sequence identity at the protein level. Stimulation with IL-10 leads to phosphorylation of JAK1 and Tyk 2 tyrosine kinases. The activated kinases phosphorylate the two tyrosine residues (Tyr 446 and Tyr 496) in the cytoplasmic domain of IL-10RÏ«. The phosphorylation of these two residues are required for proper function of IL-10R and activation of IL-10E1 signaling. IL-10RÉÇ is ubiquitously expressed and, in addition to forming the IL-10 heterodimeric receptor, it forms a heterodimeric receptor with an IL-22R subunit and an IL-28R subunit. IL-10R is constitutively expressed on human natural killer (NK) cells and the direct binding of IL-10 potentiates cytokine production by human NK cells.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot analysis of extracts of MCF-7 cell lines, using IL10RA antibody.