ABIN968692

antibody from antibodies-online

Targeting: LIG3 LIG2, LIG3alpha

Western blot (Data presented on provider website)

Antibody Data

Product number

ABIN968692

Provider

antibodies-online

Product name

anti-Ligase III, DNA, ATP-Dependent (LIG3) (AA 2-115) antibody

Antibody type

Monoclonal

Antigen

Human DNA Ligase III

Description

Purified from tissue culture supernatant or ascites by affinity chromatography.

Reactivity

Human

Host

Mouse

Epitope

AA 2-115

Isotype

IgG

Antibody clone number

7

Vial size

50 μg

Concentration

250 μg/ml

Storage

-20°C

References

Submitted references

The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joining.

Taylor RM, Whitehouse CJ, Caldecott KW
Nucleic acids research 2000 Sep 15;28(18):3558-63

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ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

Oei SL, Ziegler M
The Journal of biological chemistry 2000 Jul 28;275(30):23234-9

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DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.

Mackey ZB, Niedergang C, Murcia JM, Leppard J, Au K, Chen J, de Murcia G, Tomkinson AE
The Journal of biological chemistry 1999 Jul 30;274(31):21679-87

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Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination.

Chen J, Tomkinson AE, Ramos W, Mackey ZB, Danehower S, Walter CA, Schultz RA, Besterman JM, Husain I
Molecular and cellular biology 1995 Oct;15(10):5412-22