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Learn13588-1-AP
antibody from Proteintech Group
Targeting: GZMB
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 13588-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13588-1-AP, RRID:AB_2114429
- Product name
- Granzyme B antibody
- Antibody type
- Polyclonal
- Description
- Granzyme B antibody (Cat. #13588-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE).
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.
Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features.
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150
Frontiers in cellular and infection microbiology 2021;11:587150
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Yuan Q, Liang Q, Sun Z, Yuan X, Hou W, Wang Y, Wang H, Yu M
Oncoimmunology 2021;10(1):1914954
Oncoimmunology 2021;10(1):1914954
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F
Clinical and translational medicine 2021 Sep;11(9):e464
Clinical and translational medicine 2021 Sep;11(9):e464
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2021 Sep 25;
The Journal of investigative dermatology 2021 Sep 25;
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
Xu L, Cai P, Li X, Wu X, Gao J, Liu W, Yang J, Xu Q, Guo W, Gu Y
Toxicology and applied pharmacology 2021 Oct 1;428:115672
Toxicology and applied pharmacology 2021 Oct 1;428:115672
In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE).
Wei PS, Chen YJ, Lin SY, Chuang KH, Sheu MT, Ho HO
Biomaterials 2021 Nov;278:121166
Biomaterials 2021 Nov;278:121166
B7-H4 is increased in lung adenocarcinoma harboring EGFR-activating mutations and contributes to immunosuppression.
Lu Y, Wu F, Cao Q, Sun Y, Huang M, Xiao J, Zhou B, Zhang L
Oncogene 2021 Nov 27;
Oncogene 2021 Nov 27;
Transcriptome-Based Network Analysis Unveils Eight Immune-Related Genes as Molecular Signatures in the Immunomodulatory Subtype of Triple-Negative Breast Cancer.
Zhang J, Wang L, Xu X, Li X, Guan W, Meng T, Xu G
Frontiers in oncology 2020;10:1787
Frontiers in oncology 2020;10:1787
Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.
Cai X, Wei B, Li L, Chen X, Liu W, Cui J, Lin Y, Sun Y, Xu Q, Guo W, Gu Y
International immunopharmacology 2020 Nov;88:106858
International immunopharmacology 2020 Nov;88:106858
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Wang X, Liang C, Xia W, Guo C, Niu Z, Zhu W, Zhang H
Molecular immunology 2020 Dec;128:41-46
Molecular immunology 2020 Dec;128:41-46
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.
Zheng B, Ren T, Huang Y, Sun K, Wang S, Bao X, Liu K, Guo W
Journal of hematology & oncology 2018 Feb 6;11(1):16
Journal of hematology & oncology 2018 Feb 6;11(1):16
Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features.
Cho YT, Lin JW, Chen YC, Chang CY, Hsiao CH, Chung WH, Chu CY
Journal of the American Academy of Dermatology 2014 Mar;70(3):539-48
Journal of the American Academy of Dermatology 2014 Mar;70(3):539-48
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis.
Li P, Zheng G, Yang Y, Zhang C, Xiong P, Xu Y, Fang M, Tan Z, Zheng F, Gong F
Cellular and molecular life sciences : CMLS 2010 Sep;67(18):3197-208
Cellular and molecular life sciences : CMLS 2010 Sep;67(18):3197-208
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 13588-1-AP(GZMB antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using GZMB antibody 13588-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13588-1-AP(GZMB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lymphoma using 13588-1-AP(GZMB antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
