PAB8487

antibody from Abnova Corporation

Targeting: MDC1 Em:AB023051.5, KIAA0170, NFBD1

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

PAB8487

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#PAB8487, RRID:AB_1676442

Product name

MDC1 polyclonal antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic peptide of MDC1.

Storage

Store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways.

Xu X, Stern DF
The Journal of biological chemistry 2003 Mar 7;278(10):8795-803

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NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.

Peng A, Chen PL
The Journal of biological chemistry 2003 Mar 14;278(11):8873-6

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J
Nature 2003 Feb 27;421(6926):957-61

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MDC1 is required for the intra-S-phase DNA damage checkpoint.

Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP
Nature 2003 Feb 27;421(6926):952-6

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Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.

Lou Z, Chini CC, Minter-Dykhouse K, Chen J
The Journal of biological chemistry 2003 Apr 18;278(16):13599-602

Western blot

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Western blot analysis of extract from 293T (lane 1) and HeLa cells (lane 2) , using MDC1 polyclonal antibody (Cat # PAB8487) .