CABT-BL7446

antibody from Creative Diagnostics

Targeting: CXCR5 BLR1, CD185, MDR15

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7446

Provider

Creative Diagnostics

Product name

Anti-Cxcr5 Monoclonal antibody, clone TQSDM6 [Biotin]

Antibody type

Monoclonal

Description

CXCR5 expression has been reported in human blood and salivary gland and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This ""turn-off"" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Reactivity

Mouse

Host

Rat

Conjugate

Biotin

Isotype

IgG