335001

antibody from BioLegend

Targeting: CXCR5 BLR1, CD185, MDR15

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

335001

Provider

BioLegend

Product name

PerCP/Cy5.5 anti-human CD185 (CXCR5)

Antibody type

Monoclonal

Antigen

CD185 (CXCR5)

Description

CXCR5 is a chemokine receptor which binds to CXCL13. CXCR5 is expressed in B cells and T folicular helper (TFH) cells (1). CXCR5 is required for migration of B cells to the follicular compartment in the spleen, lymph nodes, Peyer's patches, and tonsils, and normal maturation of primary follicle follicular dendritic cells (2, 3). CXCR5 and CXCL13 contribute in the B cell homing to Peyer's patches (4). In addition, T cell CXCR5 is required for germinal center response of normal magnitude (5).

Reactivity

Human

Host

Mouse

Conjugate

Far-Red dye

Isotype

IgG

Vial size

25 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

References

Submitted references

B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses.

Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2730-6

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood lymphocytes stained with CD19 (HIB19) PE and TG2/CXCR5 PerCP/Cy5.5