VRK3

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

VRK serine/threonine kinase 3

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (49976468 - 50025946)

Ensembl ID

ENSG00000105053  (ver. 103.38)

Orthologs

Mouse Vrk3: ENSMUSG00000002205

UniProt

Q8IV63

neXtProt

NX_Q8IV63

Human splice variants
Mouse splice variants

Protein structure