orb151971

antibody from Biorbyt
Targeting: HSPB8 CMT2L, E2IG1, H11, HSP22
Provider product page for orb151971
Western blot
Immunocytochemistry
Immunoprecipitation
Immunohistochemistry

Antibody data

Product number
orb151971 - Provider product page
Provider
Biorbyt
Product name
HSP22 antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to Hsp22 (ATTO-390). Hsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta. Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27. HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs. The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macro autophagy. Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L)..
Reactivity
Human, Mouse, Rat
Host
Rabbit
Vial size
100 ul
Concentration
1 mg/ml
Storage
Conjugated antibodies should be stored at 4°C
HSPB8 protein structure - orb151971 shown in red.