Antibody data

Product number
BS5785 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CACNG1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the 177-222 of Human CACNG1.
Description
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Ï«1 subunit, a ÉÇ subunit, a ÎÛ subunit and an Ï«2Ñ´ subunit. The ÉÇ subunit is encoded by four genes, designated ÉÇ1-ÉÇ4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Ï«1 subunit. L-type Ca ++ CP ÎÛ1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP ÎÛ1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP ÎÛ1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anaesthetics and depolarizing muscle relaxants.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CACNG1 protein structure - BS5785 shown in red.